{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T22:27:29Z","timestamp":1784327249967,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T00:00:00Z","timestamp":1676246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Asthma is associated with abnormal autonomic function, and heart rate variability is considered a simple, accurate, and noninvasive tool for monitoring the autonomic system. Thus, the aim of this study was to investigate the impact of asthma on heart rate variability in children and adolescents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This systematic review of observational studies and clinical trials evaluated heart rate variability in children and adolescents with asthma compared to healthy controls. The data were extracted independently by two reviewers. The quality of the selected articles was assessed using Agency for Health Care Research and Quality indicators. Random effects meta\u2010analysis was performed for each outcome, with the effect size reported as standardized mean difference.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifteen studies were included, of which five were classified as having high methodological quality. In the meta\u2010analysis, long\u2010term recording of the standard deviation of all normal\u2010to\u2010normal sinus R\u2010R intervals differed significantly between groups (standardized mean difference [SMD]\u2009=\u2009\u22120.46 [95% confidence interval {CI}: \u22120.79 to \u22120.14], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.005, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090%). Moreover, R\u2010R intervals (long\u2010term) were significantly shorter in asthmatic children than controls (SMD\u2009=\u2009\u22120.47 [95% CI: \u22120.68 to \u22120.25], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090). There were no significant differences between adjacent normal R\u2010R intervals that exceed 50\u2009ms (long\u2010term) and the root mean square of successive differences between normal sinus R\u2010R intervals (short\u2010term). Regarding frequency\u2010domain variables, long\u2010term low frequency measurements differed significantly between groups (SMD\u2009=\u2009\u22120.34 [95% CI: \u22120.58 to \u22120.10], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.005, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200915%). There were no differences in high frequency measurements or in the ratio between low\/high frequency powers (short\u2010 or long\u2010term) between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results confirm the impact of asthma on heart rate variability in children and adolescents, indicating lower heart rate variability and sympathetic modulation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26340","type":"journal-article","created":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T13:04:35Z","timestamp":1675170275000},"page":"1310-1321","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Impact of asthma on heart rate variability in children and adolescents: Systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0041-8058","authenticated-orcid":false,"given":"Daniele","family":"Schiwe","sequence":"first","affiliation":[{"name":"Laboratory of Pediatric Physical Activity, Infant Center, Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul (PUCRS) Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8208-3476","authenticated-orcid":false,"given":"Fernanda Maria","family":"Vendrusculo","sequence":"additional","affiliation":[{"name":"Laboratory of Pediatric Physical Activity, Infant Center, Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul (PUCRS) Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4956-374X","authenticated-orcid":false,"given":"Nicolas Acosta","family":"Becker","sequence":"additional","affiliation":[{"name":"Laboratory of 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