{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T14:42:08Z","timestamp":1776436928926,"version":"3.51.2"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Neurally adjusted ventilatory assist (NAVA) is a ventilatory mode that delivers synchronized ventilation, proportional to the electrical activity of the diaphragm (EAdi). Although it has been proposed in infants with a congenital diaphragmatic hernia (CDH), the diaphragmatic defect and the surgical repair could alter the physiology of the diaphragm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate, in a pilot study, the relationship between the respiratory drive (EAdi) and the respiratory effort in neonates with CDH during the postsurgical period under either NAVA ventilation or conventional ventilation (CV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective physiological study included eight neonates admitted to a neonatal intensive care unit with a diagnosis of CDH. EAdi, esophageal, gastric, and transdiaphragmatic pressure, as well as clinical parameters, were recorded during NAVA and CV (synchronized intermittent mandatory pressure ventilation) in the postsurgical period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>EAdi was detectable and there was a correlation between the \u0394EAdi (maximal\u2009\u2212\u2009minimal values) and the transdiaphragmatic pressure (<jats:italic>r<\/jats:italic>\u2009=\u20090.26, 95% confidence interval [CI] [0.222; 0.299]). There was no significant difference in terms of clinical or physiological parameters during NAVA compared to CV, including work of breathing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Respiratory drive and effort were correlated in infants with CDH and therefore NAVA is a suitable proportional mode in this population. EAdi can also be used to monitor the diaphragm for individualized support.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26357","type":"journal-article","created":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T17:55:28Z","timestamp":1676742928000},"page":"1542-1550","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Respiratory physiology during NAVA ventilation in neonates born with a congenital diaphragmatic hernia: The \u201cNAVA\u2010diaph\u201d pilot study"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1863-3098","authenticated-orcid":false,"given":"L\u00e9lia","family":"Dreyfus","sequence":"first","affiliation":[{"name":"Service de N\u00e9onatologie et R\u00e9animation N\u00e9onatale, Hospices Civils de Lyon H\u00f4pital Femme M\u00e8re Enfant Bron 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Lyon H\u00f4pital Femme M\u00e8re Enfant Bron France"},{"name":"EA 419 Universit\u00e9 Claude Bernard Lyon 1 Villeurbanne France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0838-8914","authenticated-orcid":false,"given":"Florent","family":"Baudin","sequence":"additional","affiliation":[{"name":"Service de r\u00e9animation p\u00e9diatrique, Hospices Civils de Lyon H\u00f4pital Femme M\u00e8re Enfant Bron France"},{"name":"Unit\u00e9 APCSe (UP 2021, A101) Universit\u00e9s de Lyon, VetAgro Sup Marcy l'Etoile 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