{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T05:49:31Z","timestamp":1794376171363,"version":"4.9.0"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T00:00:00Z","timestamp":1677456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Despite the growing evidence of efficacy, little is known regarding the efficiency of ambrisentan to decrease cost and improve the functional classes of pediatric patients with pulmonary arterial hypertension. This study aims to determine the cost\u2010utility of ambrisentan regarding sildenafil to treat pediatric patients with pulmonary arterial hypertension in Colombia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A decision tree model was used to estimate the cost and quality\u2010adjusted life\u2010years (QALYs) of ambrisentan, or sildenafil in pediatric patients with pulmonary arterial hypertension. Multiple sensitivity analyses were conducted to evaluate the robustness of the model. Cost\u2010effectiveness was evaluated at a willingness\u2010to\u2010pay (WTP) value of US$5180.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The base\u2010case analysis showed that compared with sildenafil, ambrisentan was associated with higher costs and higher QALYs. The expected annual cost per patient with ambrisentan was US$16,105 and with sildenafil was US$1431. The QALYs per person estimated with ambrisentan was 0.40 and for sildenafil was 0.39. The estimated improvement in quality of life and reduced costs results in an estimate of economic dominance for sildenafil over ambrisentan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our economic evaluation shows that ambrisentan is not cost\u2010effective regarding sildenafil to treat pediatric patients with pulmonary arterial hypertension in Colombia. Our study provides evidence that should be used by decision\u2010makers to improve clinical practice guidelines.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26361","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T05:48:50Z","timestamp":1676612930000},"page":"1562-1568","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Ambrisentan for in pediatric pulmonary arterial hypertension: A cost\u2010utility analysis"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2404-6612","authenticated-orcid":false,"given":"Jefferson A.","family":"Buend\u00eda","sequence":"first","affiliation":[{"name":"Research Group in Pharmacology and Toxicology\u201dINFARTO\u201d, Department of Pharmacology and Toxicology University of Antioquia Medellin Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana G.","family":"Pati\u00f1o","sequence":"additional","affiliation":[{"name":"Research Group in Pharmacology and Toxicology\u201dINFARTO\u201d, Department of Pharmacology and Toxicology University of Antioquia Medellin Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika F.","family":"Lindarte","sequence":"additional","affiliation":[{"name":"Research Group in Pharmacology and Toxicology\u201dINFARTO\u201d, Department of Pharmacology and Toxicology University of Antioquia Medellin Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9061717"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.026591"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-115-5-343"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00005713"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2019.06.022"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.25796"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.22555"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40272-013-0052-2"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.25427"},{"issue":"2","key":"e_1_2_11_11_1","first-page":"170","article-title":"Standards of care in pulmonary hypertension","volume":"61","author":"Barbera JA","year":"2008","journal-title":"Rev Esp Cardiol"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.005698"},{"key":"e_1_2_11_13_1","article-title":"A randomized study of safety and efficacy of two doses of ambrisentan to treat pulmonary arterial hypertension in pediatric patients aged 8 years up to 18 years","volume":"5","author":"Ivy D","year":"2020","journal-title":"J Pediatr"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2006.11.009"},{"key":"e_1_2_11_15_1","unstructured":"Salud IdETe. 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