{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:35:03Z","timestamp":1791952503816,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cystic fibrosis transmembrane conductance regulator (CFTR)\u00a0modulators have shown beneficial effects on both forced expiratory volume in 1\u2009s\u00a0(FEV<jats:sub>1<\/jats:sub>) and frequency of pulmonary exacerbations in people with cystic fibrosis (CF). These positive outcomes may be related to changes in bacterial colonization within the lungs. Elexacaftor\/tezacaftor\/ivacaftor (ELX\/TEZ\/IVA)\u00a0is the first triple therapy CFTR modulator approved for use in people with CF\u00a06\u00a0years and older. This study aimed to determine the impact of ELX\/TEZ\/IVA\u00a0on the isolation of <jats:italic>Pseudomonas aeruginosa<\/jats:italic> (Pa), methicillin\u2010resistant and methicillin\u2010susceptible <jats:italic>Staphylococcus aureus<\/jats:italic> (MRSA and MSSA, respectively) in respiratory cultures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective chart review of the electronic medical record at the University of Iowa was completed for individuals 12 years and older taking ELX\/TEZ\/IVA\u00a0for at least 12 months. The primary outcome was determined by assessing bacterial cultures pre\u2010 and postinitiation of ELX\/TEZ\/IVA.\u00a0Baseline demographic and clinical characteristics were summarized using mean and standard deviation for continuous outcomes and count and percentage for categorical outcomes. Culture positivity for Pa, MSSA, and MRSA was compared among enrolled subjects between pre\u2010 and posttriple combination therapy periods using an exact McNemar's test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and twenty\u2010four subjects prescribed ELX\/TEZ\/IVA\u00a0for at least 12 months met the requirements for inclusion within our analysis. Culture positivity for Pa, MSSA, and MRSA was approximately 54%, 33%, and 31%, respectively, for the pre\u2010ELX\/TEZ\/IVA\u00a0period. Prevalence decreased to approximately 30%, 32%, and 24% (\u221224.2% [<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001], \u22120.7% [<jats:italic>p<\/jats:italic>\u2009=\u20091.00], and \u22126.5% [<jats:italic>p<\/jats:italic>\u2009=\u20090.0963], respectively) post\u2010ELX\/TEZ\/IVA.\u00a0The source of bacterial culture was predominantly sputum (70.2%) in the pre\u2010ELX\/TEZ\/IVA\u00a0group, whereas a throat source (66.1%) was more common post\u2010ELX\/TEZ\/IVA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ELX\/TEZ\/IVA\u00a0treatment has an appreciable impact on the detection of common bacterial pathogens in CF respiratory cultures. While previous studies have found a similar effect with single and double CFTR modulator therapies, this is the first single\u2010center study to show the impact of triple therapy, ELX\/TEZ\/IVA,\u00a0on bacterial isolation from airway secretions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26362","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T11:09:23Z","timestamp":1676891363000},"page":"1569-1573","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Impact of elexacaftor\/tezacaftor\/ivacaftor on bacterial cultures from people with cystic fibrosis"],"prefix":"10.1002","volume":"58","author":[{"given":"Michael R.","family":"Beck","sequence":"first","affiliation":[{"name":"University of Iowa Hospitals and Clinics Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas B.","family":"Hornick","sequence":"additional","affiliation":[{"name":"University of Iowa Hospitals and Clinics Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6114-6861","authenticated-orcid":false,"given":"Tahuanty A.","family":"Pena","sequence":"additional","affiliation":[{"name":"University of Iowa Hospitals and Clinics Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachinkumar B.","family":"Singh","sequence":"additional","affiliation":[{"name":"University of Iowa Hospitals and Clinics Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6620-1727","authenticated-orcid":false,"given":"Brittany A.","family":"Wright","sequence":"additional","affiliation":[{"name":"University of Iowa Hospitals and Clinics Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Cystic Fibrosis Foundation.About cystic fibrosis. Accessed February 15 2022.2020.https:\/\/www.cff.org\/intro-cf\/about-cystic-fibrosis"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199607183350307"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200304-505SO"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1105185"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1409547"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1709847"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1709846"},{"key":"e_1_2_9_9_1","unstructured":"CF Foundation. Registry.\u00a02020.\u00a0https:\/\/www.cff.org\/medical-professionals\/patient-registry"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201609-1954OC"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201404-0703OC"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu944"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.03148-21"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2014.02.004"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.202008-1054OC"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1908639"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2100665"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32597-8"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac117"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2021.11.003"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2021.02.003"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202108-1986OC"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.26362","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ppul.26362","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.26362","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T07:48:00Z","timestamp":1710834480000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.26362"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1002\/ppul.26362"],"URL":"https:\/\/doi.org\/10.1002\/ppul.26362","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"2022-07-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}