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There is no available vaccine, with treatment limited to supportive care or palivizumab for high\u2010risk children. Additionally, although a causal relationship has not been established, RSV has been associated with the development of asthma or wheezing in some children. The COVID\u201019 pandemic and the introduction of nonpharmaceutical interventions (NPIs) have caused substantial changes to RSV seasonality and epidemiology. Many countries have experienced an absence of RSV during the time of a typical season, followed by an out\u2010of\u2010season surge upon relaxation of NPI use. These dynamics have disrupted traditional RSV disease patterns and assumptions, but also provide a unique opportunity to learn more about the transmission of RSV and other respiratory viruses, as well as inform future approaches to RSV preventive strategies. Here, we review the\u00a0RSV burden and epidemiology through the COVID\u201019 pandemic and discuss how new data may affect future decisions regarding RSV prevention.<\/jats:p>","DOI":"10.1002\/ppul.26370","type":"journal-article","created":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T05:14:35Z","timestamp":1677042875000},"page":"1631-1639","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["RSV through the COVID\u201019 pandemic: Burden, shifting epidemiology, and implications for the future"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0269-0757","authenticated-orcid":false,"given":"Renato T.","family":"Stein","sequence":"first","affiliation":[{"name":"Infant Center, Department of Pediatrics, School of Medicine Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather 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