{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T10:30:48Z","timestamp":1785234648250,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T00:00:00Z","timestamp":1679011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Asthma is a common disease in childhood with a minority of affected children suffering from severe asthma. Patients with severe asthma require high dose inhaled glucocorticoids plus a second controller and\/or systemic corticosteroids to be well\u2010controlled or remain uncontrolled despite such treatment. Although only a small subset of children and adolescents falls in this category, the management of affected patients represents a major concern for pediatricians. Guidelines and recommendations have been designed to guide the management of this group of patients. Though the terms \u201crecommendations\u201d and \u201cguidelines\u201d are often used interchangeably, it should be noted that the first one should be used more narrowly to identify specific actions and the second one to broadly refer to the umbrella under which multiple recommendations for a specific condition are provided. Moreover, the availability of several and sometimes\u2010conflicting documents on severe asthma management both in adult and pediatric age could generate confusion among health care professionals. The manuscript analyses seven papers addressing severe asthma, comparing any key aspects and differences. Finally, we tried to create a more practical document for physicians to simplify the interpretation of the several available documents on severe asthma management focusing the pediatric age.<\/jats:p>","DOI":"10.1002\/ppul.26387","type":"journal-article","created":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T13:34:48Z","timestamp":1679060088000},"page":"1640-1650","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Severe asthma guidelines in children and adolescents: A practical document for physicians"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7779-728X","authenticated-orcid":false,"given":"Federica","family":"Porcaro","sequence":"first","affiliation":[{"name":"Pediatric Pulmonology and Cystic Fibrosis Unit, Bambino Ges\u00f9 Children's Hospital IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1111-5690","authenticated-orcid":false,"given":"Nicola","family":"Ullmann","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology and Cystic Fibrosis Unit, Bambino Ges\u00f9 Children's Hospital IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Di Marco","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology and Cystic Fibrosis Unit, Bambino Ges\u00f9 Children's Hospital IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Allegorico","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology and Cystic Fibrosis Unit, Bambino Ges\u00f9 Children's Hospital IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1628-5488","authenticated-orcid":false,"given":"Claudio","family":"Cherchi","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology and Cystic Fibrosis Unit, Bambino Ges\u00f9 Children's Hospital IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Giovanna","family":"Paglietti","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology and Cystic Fibrosis Unit, Bambino Ges\u00f9 Children's Hospital IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7711-5672","authenticated-orcid":false,"given":"Renato","family":"Cutrera","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology and Cystic Fibrosis Unit, Bambino Ges\u00f9 Children's Hospital IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02094-2020"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000815"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2021.04.031"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01672.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/children7120286"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2018.00276"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2019.00028"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00202013"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.04.014"},{"key":"e_1_2_10_11_1","unstructured":"NICE. Asthma: diagnosis monitoring and chronic asthma management. 2022.https:\/\/www.nice.org.uk\/guidance\/ng80"},{"key":"e_1_2_10_12_1","unstructured":"British Thoracic Society. Better lung health for all. 2022.https:\/\/www.brit-thoracic.org.uk\/quality-improvement\/guidelines\/asthma\/"},{"key":"e_1_2_10_13_1","unstructured":"NHLBI NIH. National Asthma Education and Prevention Program (NAEPP). 2022.https:\/\/www.nhlbi.nih.gov\/science\/national-asthma-education-and-prevention-program-naepp"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00588-2019"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00318-2020"},{"key":"e_1_2_10_16_1","unstructured":"Global Initiative for Asthma. Diagnosis and Management of Difficult\u2010to\u2010treat and Severe Asthma. 2022.https:\/\/ginasthma.org\/severeasthma\/"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/24745332.2017.1395250"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.920066"},{"key":"e_1_2_10_19_1","unstructured":"Mepolizumab for treating severe eosinophilic asthma. :14."},{"key":"e_1_2_10_20_1","unstructured":"Reslizumab for treating severe eosinophilic asthma. :27."},{"key":"e_1_2_10_21_1","unstructured":"Dupilumab for treating severe asthma with type 2 inflammation. :25."},{"key":"e_1_2_10_22_1","unstructured":"Omalizumab for treating severe persistent allergic asthma. :62."},{"key":"e_1_2_10_23_1","doi-asserted-by":"crossref","unstructured":"Benralizumab for treating severe eosinophilic asthma.2019;24.","DOI":"10.1016\/j.anai.2019.08.246"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.125.4.1378"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.26387","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ppul.26387","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.26387","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T19:43:21Z","timestamp":1692560601000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.26387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,17]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1002\/ppul.26387"],"URL":"https:\/\/doi.org\/10.1002\/ppul.26387","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,17]]},"assertion":[{"value":"2022-08-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}