{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T14:46:42Z","timestamp":1785336402207,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T00:00:00Z","timestamp":1682467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>With the increase in macrolide\u2010resistant <jats:italic>M. pneumoniae<\/jats:italic> infections, off\u2010label use is difficult to avoid. This study assessed the safety of moxifloxacin in pediatric patients with severe refractory <jats:italic>M. pneumoniae<\/jats:italic> pneumonia (SRMPP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed the medical records of children with SRMPP between January 2017 and November 2020 at Beijing Children's Hospital. They were divided into the moxifloxacin group and azithromycin group according to whether or not moxifloxacin was used. The clinical symptoms, radiographs of both knees, and cardiac ultrasounds of the children were collected after drug withdrawal for at least 1 year. A multidisciplinary team reviewed all adverse events and determined their relationship with moxifloxacin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 52 children with SRMPP were included in this study (31 in the moxifloxacin group and 21 in the azithromycin group). In the moxifloxacin group, four patients had arthralgia, one had joint effusion, and seven had heart valve regurgitation. In the azithromycin group, three patients had arthralgia, one had claudication, and one had heart valve regurgitation; no obvious knee abnormalities were observed in the radiographs. No statistically significant differences in clinical symptoms or imaging findings were found between the groups. As for the adverse events, 11 patients in moxifloxacin group were deemed to be doubtfully related and one possibly related to moxifloxacin; in the azithromycin group, four patients were regarded to be doubtfully related to azithromycin and one not related.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Moxifloxacin was well tolerated and safe for treating SRMPP in children.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26426","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T13:24:11Z","timestamp":1682515451000},"page":"2017-2024","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Safety study of moxifloxacin in children with severe refractory <i>Mycoplasma pneumoniae<\/i> pneumonia"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3585-8579","authenticated-orcid":false,"given":"Yu\u2010Shan","family":"He","sequence":"first","affiliation":[{"name":"Pediatric Intensive Care Unit, Beijing Children's Hospital, National Center for Children's Health Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Beijing Children's Hospital, National Center for Children's Health Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Liu","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, Beijing Children's Hospital, National Center for Children's Health Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Ji","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, Beijing Children's Hospital, National Center for Children's Health Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su\u2010Yun","family":"Qian","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, Beijing Children's Hospital, National Center for Children's Health Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00114-16"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2011.02102.x"},{"key":"e_1_2_10_4_1","first-page":"745","article-title":"The subspecialty group of respiratory disease, the Society of Pediatrics, Chinese Medical Association, The Editorial Board, Chinese Journal of Pediatrics. 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