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Chylothorax resistant to medical therapy and drainage is often treated by chemical pleurodesis. Previously used pleurodesis agents have included talc, minocycline, OK\u2010432, bleomycin, and povidone\u2010iodine. 50% Dextrose (D50) has been reported to be useful for pleurodesis in adults. We successfully managed two cases of prematurely born infants with D50 as an alternative chemical sclerosant for chemical pleurodesis in a resistant chylothorax and discussed evidence of its use in the literature<\/jats:p>","DOI":"10.1002\/ppul.26436","type":"journal-article","created":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T12:05:01Z","timestamp":1683893101000},"page":"2145-2150","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Hypertonic glucose pleurodesis for preterm neonates with chylothorax"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6682-5529","authenticated-orcid":false,"given":"Kam Lun Ellis","family":"Hon","sequence":"first","affiliation":[{"name":"Department of Paediatrics, CUHKMC The Chinese University of Hong Kong  Hong Kong SAR China"},{"name":"Department of Paediatrics and Adolescent Medicine Hong Kong Children's Hospital  Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuk Man Peter","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Hong Kong Children's Hospital  Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genevieve P. 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