{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T08:45:05Z","timestamp":1780044305570,"version":"3.53.1"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T00:00:00Z","timestamp":1683244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016032","name":"Nederlandse Cystic Fibrosis Stichting","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016032","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011022","name":"Vertex Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011022","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>eHealth CF\u2010CBT is the first digital mental health intervention for depression\/anxiety in adults with cystic fibrosis (awCF); an 8\u2010session therapist\u2010guided internet\u2010delivered program that was developed in English and Dutch with stakeholder input and evaluation indicating high acceptability and usability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Dutch eHealth CF\u2010CBT was piloted in awCF with mild\u2010moderate symptoms of depression and\/or anxiety. Feasibility, usability, acceptability, and preliminary efficacy were assessed, measuring pre\u2010post changes in depression (PHQ\u20109), anxiety (GAD\u20107), perceived stress (PSS), and health\u2010related quality of life (CFQ\u2010R).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All participants (<jats:italic>n<\/jats:italic>\u2009=\u200910, seven female, mean age 29 [range 21\u201343], mean FEV1 71%pred [range 31\u2013115]) completed all sessions. Patient\u2010rated feasibility, usability, and acceptability of eHealth CF\u2010CBT were positive on validated scales, as were qualitative assessments of content and format. GAD\u20107 improved in 90% of participants; in 50% by \u2265the minimally important difference (MID) of four points. PHQ\u20109 improved in 90%; 40% by \u2265the MID of 5. PSS improved in 80%. CFQ\u2010R improved in the domain health perceptions (70%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>eHealth CF\u2010CBT demonstrated feasibility, usability, acceptability, and promising preliminary efficacy in this pilot trial with Dutch awCF with mild to moderate symptoms of depression and anxiety.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26438","type":"journal-article","created":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T12:41:45Z","timestamp":1683290505000},"page":"2094-2103","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Pilot of a therapist\u2010guided digital mental health intervention (eHealth CF\u2010CBT) for adults with cystic fibrosis"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2787-5440","authenticated-orcid":false,"given":"Marieke","family":"Verkleij","sequence":"first","affiliation":[{"name":"Amsterdam UMC Location University of Amsterdam, Emma Children's Hospital, Child and Adolescent Psychiatry &amp; 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