{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T20:03:06Z","timestamp":1774641786529,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T00:00:00Z","timestamp":1683244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the validity and reliability of the modified shuttle 25\u2010level test (MST\u201025) in children with cystic fibrosis (CF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective single center study in clinically stable children with CF. Participants undertook two testing conditions on different days: (1) 2xMST\u201025 tests; (2) cardiopulmonary exercise test (CPET). Test order was randomized. Nadir oxygen saturation (SpO<jats:sub>2<\/jats:sub>), peak heart rate (HR), breathlessness (modified Borg), rate of perceived exertion (RPE), energy expenditure (EE) and metabolic equivalents (MET) from the MST\u201025 and CPET were compared to assess validity, while outcomes from 2xMST\u201025 tests were compared for reliability. CPET was performed using breath\u2010by\u2010breath analysis and EE from the MST\u201025 obtained using the SenseWear Armband.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Strong correlations were found between MST\u201025 distance and peak oxygen uptake, peak work and minute ventilation on CPET (all <jats:italic>r<\/jats:italic>\u2009&gt;\u20090.7, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Moderate correlations were found between MST\u201025 distance and CPET for METs (<jats:italic>r<\/jats:italic>\u2009=\u20090.5) and HR (<jats:italic>r<\/jats:italic>\u2009=\u20090.6). Weak associations between tests were evident for nadir SpO<jats:sub>2<\/jats:sub> (<jats:italic>r<\/jats:italic>\u2009=\u20090.1), modified Borg (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>\u2009=\u20090.2) and RPE (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>\u2009=\u20090.2). Test\u2212retest reliability was excellent for MST\u201025 distance (ICC 0.91), peak EE (ICC 0.99) and peak METs (ICC 0.90). Good reliability was achieved for HR (ICC 0.84) and modified Borg score (ICC 0.77), while moderate reliability for nadir SpO<jats:sub>2<\/jats:sub> (ICC 0.64) and RPE (ICC 0.68) was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The MST\u201025 is a valid and reliable field test for the assessment of exercise capacity in children with CF. The MST\u201025 can be used to accurately monitor exercise capacity and prescribe exercise training, particularly when CPET is not available.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26452","type":"journal-article","created":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T12:47:05Z","timestamp":1683290825000},"page":"2240-2248","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Validation of the 25 level modified shuttle test in children with cystic fibrosis"],"prefix":"10.1002","volume":"58","author":[{"given":"Jennifer","family":"Corda","sequence":"first","affiliation":[{"name":"Department of Physiotherapy Royal Children's Hospital Melbourne Australia"},{"name":"Department of Physiotherapy La Trobe University Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"E. 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