{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T09:20:04Z","timestamp":1783416004272,"version":"3.54.6"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T00:00:00Z","timestamp":1684454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Clinical trial research have provided evidence that omega\u20103 may have larger potential benefits for treating cystic fibrosis (CF). This study's objective was to assess the impact of three supplementation on pediatric CF patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Scopus, PubMed\/Medline, Web of Science, Cochrane, and Embase databases were searched from commencement until July 20, 2022 using standard keywords to identify all randomized controlled studies (RCTs) examining the effects of omega\u20103 supplementation on young patients with CF. The eligible studies were subjected to a random\u2010effects model meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A meta\u2010analysis of 12 the eligible studies was performed. Findings of the study showed that omega\u20103 supplementation significantly increased the levels of docosahexaenoic acid (weighted mean [WMD]: 2.06%, 95% confidence interval [CI]: 1.29, 2.82, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and eicosapentaenoic acid (WMD: 0.32%, 95% CI: 0.15, 0.48, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) as well as decreased arachidonic acid (WMD: \u22120.78%, 95% CI: \u22121.50, \u22120.05, <jats:italic>p<\/jats:italic>\u2009=\u20090.035) and C\u2010receptive protein (CRP) (WMD: \u22123.76\u2009mg\/L, 95% CI: \u22127.42, \u22120.10, <jats:italic>p<\/jats:italic>\u2009=\u20090.044) especially when used in higher doses and for a longer period of time compared to the control group. However, no significant effect was observed on other factors including forced expiratory volume 1, forced vital capacity as well as anthropometric parameters. In addition, high heterogeneity was reported for all fatty acids, but heterogeneity was low and nonsignificant for other variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The finding showed that in pediatric patients with CF, omega\u20103 supplementation showed benefits only in plasma fatty acid profile and serum CRP.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26491","type":"journal-article","created":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T12:54:25Z","timestamp":1684500865000},"page":"2219-2228","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of omega\u20103 supplementation on children and adolescents patients with cystic fibrosis: A systematic review and meta\u2010analysis of randomized\u2010controlled trials"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6723-7112","authenticated-orcid":false,"given":"Mohammad Hassan","family":"Sohouli","sequence":"first","affiliation":[{"name":"Student Research Committee, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology Shahid Beheshti University of Medical Sciences Tehran Iran"},{"name":"Pediatric Gastroenterology and Hepatology Research Center, Department of Pediatric, Children's Medical Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elma Izze da Silva","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Postgraduate Programm in Food, Nutrition and Health, Department of Clinical Nutrition and Dietetics Federal University of Rio Grande do Sul S\u00e3o Lu\u00eds MA Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Ghahramani","sequence":"additional","affiliation":[{"name":"Pediatric Respiratory and Sleep Medicine Research Center, Department of Pediatric, Children's Medical Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Nasresfahani","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology and Hepatology Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neda","family":"Ezoddin","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Hepatology Research Center, Department of Pediatric, Children's Medical Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parastoo","family":"Sharifi","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Hepatology Research Center, Department of Pediatric, Children's Medical Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pejman","family":"Rohani","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Hepatology Research Center, Department of Pediatric, Children's Medical Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,19]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Cystic Fibrosis: Pathophysiology of Lung Disease. Seminars in Respiratory and Critical Care Medicine","author":"Bergeron C","year":"2019"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(19)30337-6"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes11060589"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2017.03.006"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24521"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2005.10.011"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181b47967"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2016.03.014"},{"issue":"4","key":"e_1_2_9_10_1","article-title":"Omega\u20103 fatty acid supplementation for cystic fibrosis","volume":"2020","author":"Watson H","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2021.105906"},{"key":"e_1_2_9_12_1","unstructured":"HigginsJ WellsG. Cochrane handbook for systematic reviews of interventions.2011."},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.116.013052"},{"key":"e_1_2_9_14_1","unstructured":"HigginsJ.Cochrane handbook for systematic reviews of interventions. Version 5.1. 0 [updated March 2011].The Cochrane Collaboration.www.cochrane-handbook.org.2011."},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-5-13"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2007.12.005"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12041014"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2020.102186"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2012.10.002"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2005.05.006"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/014860710302700152"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200010000-00016"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950180404"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2018.09.026"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2016.08.011"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24129"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088103"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.26491","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T09:45:16Z","timestamp":1702028716000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.26491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,19]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1002\/ppul.26491"],"URL":"https:\/\/doi.org\/10.1002\/ppul.26491","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,19]]},"assertion":[{"value":"2022-11-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}