{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T02:22:20Z","timestamp":1769826140582,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T00:00:00Z","timestamp":1686700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>People with cystic fibrosis (PwCF) have chronic lung disease and may be at increased risk of coronavirus disease 2019 (COVID\u201019)\u2010related morbidity and mortality. This study aimed to determine seroprevalence and clinical characteristics of severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) infection in children with cystic fibrosis (CF), and to assess antibody responses following SARS\u2010CoV\u20102 infection or vaccination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Children and adolescents with CF followed at Seattle Children's Hospital were enrolled between July 20, 2020 and February 28, 2021. SARS\u2010CoV\u20102 serostatus was determined on enrollment at 6 and 11 months (\u00b12 months) for nucleocapsid and spike IgG. Participants completed intake and weekly surveys inquiring about SARS\u2010CoV\u20102 exposures, viral\/respiratory illnesses, and symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 125 PwCF enrolled, 14 (11%) had positive SARS\u2010CoV\u20102 antibodies consistent with recent or past infection. Seropositive participants were more likely to identify as Hispanic (29% vs. 8%,<jats:italic>p<\/jats:italic>\u2009=\u20090.04) and have pulmonary exacerbations requiring oral antibiotics in the year prior (71% vs. 41%,<jats:italic>p<\/jats:italic>\u2009=\u20090.04). Five seropositive individuals (35.7%) were asymptomatic, while six (42.9%) reported mild symptoms, primarily cough and nasal congestion. Antispike protein IgG levels were approximately 10\u2010fold higher in participants following vaccination compared with participants who had natural infection alone (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and resembled levels previously reported in the general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A majority of PwCF have mild or no symptoms of SARS\u2010CoV\u20102 making it difficult to distinguish from baseline respiratory symptoms. Hispanic PwCF may be disproportionately impacted, consistent with racial and ethnic COVID\u201019 disparities among the general US population. Vaccination in PwCF generated antibody responses similar to those previously reported in the general population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26528","type":"journal-article","created":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T12:32:25Z","timestamp":1686745945000},"page":"2478-2486","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Seroprevalence and clinical characteristics of SARS\u2010CoV\u20102 infection in children with cystic fibrosis"],"prefix":"10.1002","volume":"58","author":[{"given":"Georgene E.","family":"Hergenroeder","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Sleep Medicine Seattle Children's Hospital Seattle Washington USA"},{"name":"Department of Pediatrics University of Washington Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna V.","family":"Faino","sequence":"additional","affiliation":[{"name":"Core for 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