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Individuals were classified as experiencing hypoglycemia on OGTT (glucose &lt;70\u2009mg\/dL) or not. Insulin, C\u2010peptide, glucose, glucagon, and incretins were measured. CGM was performed for 7 days in the free\u2010living setting. Measures of insulin sensitivity, beta cell function accounting for insulin sensitivity, and insulin clearance were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 57 participants (40 CF and 17 HC) underwent assessment. Rates of hypoglycemia by OGTT were similar in pwCF (53%, 21\/40) compared to HC (35%, 6\/17), <jats:italic>p<\/jats:italic>\u2009=\u20090.23. PwCF compared to HC had higher A1c; on OGTT higher and later glucose peaks, later insulin peaks; and on CGM more glucose variability. CF Hypo+ versus CF Hypo\u2212 had higher lung function, higher insulin sensitivity, higher beta cell function accounting for insulin sensitivity, and decreased CGM variability. When comparing CF Hypo+ to HC Hypo+, although rates of hypoglycemia are similar, pwCF had blunted glucagon responses to hypoglycemia. OGTT hypoglycemia was not associated with CGM hypoglycemia in any group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Youth with CF have increased insulin sensitivity and impaired glucagon response to hypoglycemia on OGTT. Hypoglycemia on OGTT did not associate with free\u2010living hypoglycemia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26533","type":"journal-article","created":{"date-parts":[[2023,6,25]],"date-time":"2023-06-25T00:19:59Z","timestamp":1687652399000},"page":"2495-2504","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Hypoglycemia in children and young adults with cystic fibrosis during oral glucose tolerance testing vs. continuous glucose monitoring"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0994-5743","authenticated-orcid":false,"given":"Erin","family":"Finn","sequence":"first","affiliation":[{"name":"Section of Pediatric Endocrinology, Department of Pediatrics, Children's Hospital Colorado University of Colorado Anschutz Medical Campus Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron","family":"Severn","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Colorado Anschutz Medical Campus Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Pyle","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Colorado Anschutz Medical Campus Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Garrish","sequence":"additional","affiliation":[{"name":"Department of Applied Mathematics and Statistics Colorado School of Mines Golden Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Vigers","sequence":"additional","affiliation":[{"name":"Section of Pediatric Endocrinology, Department of Pediatrics, Children's Hospital Colorado University of Colorado Anschutz Medical Campus Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia G. 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