{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T20:34:54Z","timestamp":1776544494815,"version":"3.51.2"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T00:00:00Z","timestamp":1687305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This retrospective study aimed to describe the clinical and radiological features, diagnostic methods, laboratory findings, organ involvement, and treatment strategies of 22 patients who followed up with late\u2010onset childhood sarcoidosis and compare them with the literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Method<\/jats:title><jats:p>This retrospective multicenter study reviewed the medical records of 22 children with sarcoidosis who applied to the Pediatric pulmonology department of Erciyes University Faculty of Medicine and Necmettin Erbakan Faculty of Medicine in 2012 and 2022.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of the patients at the time of diagnosis was 13.1\/year (interquartile range [IQR]1:6.3\u2010[IQR]3:15.7). The most common first presenting symptom was cough 40.9% (<jats:italic>n<\/jats:italic>\u2009=\u20099), weight loss 31.8% (<jats:italic>n<\/jats:italic>\u2009=\u20097), and dyspnea 22.7% (<jats:italic>n<\/jats:italic>\u2009=\u20095). There were elevated levels of C\u2010reactive protein (CRP; 59%), angiotensin\u2010converting enzyme (ACE; 54.5%), erythrocyte sedimentation rate (ESR; 54.5%), and immunoglobulin G (IgG; 54.5%). Twenty patients (90%) received systemic steroid treatment. Eighteen (81.8%) of these patients responded positively to treatment. Two patients had a recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The incidence of sarcoidosis in children in Turkey is currently unknown. However, a regional average of 2.2 cases per year has been documented for the first time. Contrary to previous studies, a significant prevalence of consanguineous marriage was observed in our study. While constitutional symptoms were most common in other studies, the cough was the most common symptom in our study. To our knowledge, this is one of the Turkish studies with the highest number of sarcoidosis in children and one of the few European studies on sarcoidosis in children.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26564","type":"journal-article","created":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T14:06:54Z","timestamp":1687356414000},"page":"2619-2627","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Childhood sarcoidosis in the middle Anatolia of Turkey"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6226-0340","authenticated-orcid":false,"given":"Melih","family":"Hang\u00fcl","sequence":"first","affiliation":[{"name":"Division of Pediatric Pulmonology, Department of Pediatrics Erciyes University Kayseri Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3003-918X","authenticated-orcid":false,"given":"Mehmet","family":"K\u00f6se","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonology, Department of Pediatrics Erciyes University Kayseri Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8059-902X","authenticated-orcid":false,"given":"Sevgi","family":"Pekcan","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonology, Department of Pediatrics Necmettin Erbakan University Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Ersoy","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonology, Department of Pediatrics Erciyes University Kayseri Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gokcen","family":"Unal","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonology, Department of Pediatrics Necmettin Erbakan University Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1378-9250","authenticated-orcid":false,"given":"Hanife Tugce","family":"Caglar","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonology, Department of Pediatrics Necmettin Erbakan University Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1546-0096-6-16"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mps.2000.105929"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2013-101532"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071714"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(199609)22:3<195::AID-PPUL9>3.0.CO;2-O"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.2.ats4-99"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034805"},{"key":"e_1_2_9_9_1","first-page":"149","article-title":"ATS\/ERS\/WASOG statement on sarcoidosis. 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