{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:20:49Z","timestamp":1790882449244,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T00:00:00Z","timestamp":1689033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Incidence of severe <jats:italic>M. pneumoniae<\/jats:italic> pneumonia (SMPP) reported in China has been increasing over the last decade. We aimed to evaluate the clinical features of pediatric SMPP with pulmonary complications, according to laboratory tests and chest radiographic resolution patterns.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>We retrospectively reviewed 93 SMPP patients between January 2016 and February 2019, and grouped them by pneumonia pattern: pulmonary complications (63 patients) and extensive lung lesions without pulmonary complications (30 patients).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SMPP patients with pleural effusion (medium or large) and necrotizing pneumonia showed longer duration of fever, high serum value of lactate dehydrogenase (LDH), <jats:sc>d<\/jats:sc>\u2010dimer, and LDH to albumin ratio (LAR). LAR and\u00a0\n<jats:sc>d<\/jats:sc>\u2010dimer were associated with moderate or massive pleural effusion, and\u00a0\n<jats:sc>d<\/jats:sc>\u2010dimer was associated with lung necrosis. The average time of radiographic resolution in the pulmonary complication group was 12 weeks, while those with elevated d\u2010dimer were significantly more likely to have longer time for radiographic clearance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We conclude that <jats:italic>M. pneumoniae<\/jats:italic> pneumonia in patients with pleural effusion (medium or large) or lung necrosis was more severe than those without pulmonary complications. LAR and\u00a0\n<jats:sc>d<\/jats:sc>\u2010dimer might be used as parameters to identify children susceptible to pleural effusion (medium or large) or lung necrosis, and longer time for radiographic clearance among pediatric patients of SMPP.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26593","type":"journal-article","created":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T12:28:50Z","timestamp":1689078530000},"page":"2815-2822","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Clinical features of severe <i>Mycoplasma pneumoniae<\/i> pneumonia with pulmonary complications in childhood: A retrospective study"],"prefix":"10.1002","volume":"58","author":[{"given":"Xue qin","family":"Luo","sequence":"first","affiliation":[{"name":"Division of Respiratory Medicine of Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders (Chongqing) China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Luo","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine of Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders (Chongqing) China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong jie","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine of Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders (Chongqing) China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng xiu","family":"Luo","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine of Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders (Chongqing) China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dai yin","family":"Tian","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine of Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders (Chongqing) China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5297-9578","authenticated-orcid":false,"given":"Xiao hong","family":"Xie","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine of Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders (Chongqing) China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,11]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268819000839"},{"key":"e_1_2_12_3_1","first-page":"523","article-title":"[Bronchitis obliterans associated with bronchiolitis obliterans with organizing pneumonia in a child and literature review]","volume":"54","author":"Han Q","year":"2016","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-08861-7"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000002029"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2020.08.018"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24327"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.22887"},{"key":"e_1_2_12_9_1","first-page":"745","article-title":"Guidelines for management of community acquired pneumonia in children (the revised edition of 2013) (I)","volume":"51","author":"The Subspecialty Group of Respiratory Disease, The Society of Pediatrics, Chinese Medical Association, The Editorial Board, Chinese Journal of Pediatrics","year":"2013","journal-title":"Chin J Pediatr"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20478"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-014-2054-6"},{"key":"e_1_2_12_12_1","article-title":"Accuracy of serum LDH elevation for the diagnosis of Pneumocystis jiroveci pneumonia","volume":"141","author":"Vogel M","year":"2011","journal-title":"Swiss Med Wkly"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2015.07.009"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2009.00091"},{"key":"e_1_2_12_15_1","first-page":"956","article-title":"Venous thrombosis and pulmonary embolism in a child with pneumonia due to Mycoplasma pneumoniae","volume":"101","author":"Graw\u2010Panzer KD","year":"2009","journal-title":"J Natl Med Assoc"},{"key":"e_1_2_12_16_1","first-page":"151","article-title":"[Clinical analysis of pulmonary embolism in a child with Mycoplasma pneumoniae pneumonia]","volume":"50","author":"Su HY","year":"2012","journal-title":"Zhonghua er ke za zhi"},{"key":"e_1_2_12_17_1","first-page":"1482","article-title":"Mycoplasma pneumonia combined with pulmonary infarction in a child","volume":"8","author":"Zhuo Z","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2011.02.008"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.3345\/kjp.2014.57.6.271"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-023719"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2011.10.019"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.4.1087"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-6-3"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.26593","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T14:43:47Z","timestamp":1703774627000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.26593"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,11]]},"references-count":22,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/ppul.26593"],"URL":"https:\/\/doi.org\/10.1002\/ppul.26593","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,11]]},"assertion":[{"value":"2022-07-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}