{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T16:19:56Z","timestamp":1781194796171,"version":"3.54.1"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T00:00:00Z","timestamp":1690329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The purpose of this study is to describe the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS\u2010CoV2) disease characteristics and management in children admitted to the pediatric intensive care units (PICU).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The present study was based on a national multicentric prospective registry including PICU patients with SARS\u2010CoV2 infection or symptoms of multisystem inflammatory syndrome in children (MIS\u2010C).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 298 patients were admitted to 41 different Spanish PICUs. A total of 76% of them were previously healthy. The most frequent manifestation was MIS\u2010C (69.8%). On admission, 59.4% of patients did not have respiratory distress, and only 17.4% needed conventional mechanical ventilation (MV). The need for MV was associated with age (incidence rate ratios\u00a0[IRR] 1.21, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.012), pediatric sequential organ failure assessment score\u00a0(p\u2010SOFA) Score (IRR 1.12, <jats:italic>p<\/jats:italic>\u2009=\u2009.001), and need for transfusion (IRR 4.5, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.004) in MIS\u2010C patients, and with vasoactive drug use (IRR 2.73, <jats:italic>p<\/jats:italic>\u2009=\u2009.022) and the diagnosis of acute respiratory distress syndrome (IRR 2.83, <jats:italic>p<\/jats:italic>\u2009=\u2009.018) in patients admitted for other reasons. During the first day of admission, 56% of patients met shock criteria and 50.7% needed vasoactive drugs. In MIS\u2010C patients, their use was associated with higher p\u2010SOFA score (IRR 1.06, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and with the diagnosis of shock (IRR 5.78, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). In patients without MIS\u2010C, it was associated with higher p\u2010SOFA score (IRR 1.05, <jats:italic>p<\/jats:italic>\u2009=\u2009.022). The mortality rate was 3%, being lower in MIS\u2010C patients compared to patients admitted for other reasons (0.5% vs. 9.4%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). It was also lower in previously healthy patients compared to patients with previous comorbidities (0.9% vs. 9.7%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Severe SARS\u2010CoV2 infection is uncommon in the pediatric population. In our series, respiratory distress was rare, being MIS\u2010C the most frequent cause of PICU admission related to SARS\u2010CoV2. In most cases, the course of the disease was mild except in children with previous diseases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26613","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T10:45:46Z","timestamp":1690368346000},"page":"2916-2929","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Characteristics and management of patients with SARS\u2010CoV2 infection admitted to pediatric intensive care units: Data analysis of the Spanish national multicenter registry"],"prefix":"10.1002","volume":"58","author":[{"given":"Mar\u00eda","family":"Sl\u00f6cker Barrio","sequence":"first","affiliation":[{"name":"Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Development Origin Network (RICORS) RD21\/0012\/0011 Instituto de Salud Carlos III Madrid Spain"},{"name":"Pediatric Intensive Care Unit Hospital General Universitario Gregorio 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