{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T23:28:44Z","timestamp":1770334124331,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T00:00:00Z","timestamp":1692316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Small\u2010for\u2010gestational\u2010age (SGA) preterm infants are at increased risk of developing bronchopulmonary dysplasia (BPD). There is limited information on pulmonary oxygen diffusion of SGA preterm infants, particularly in those without BPD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the pulmonary oxygen diffusion of SGA to that of appropriate\u2010for\u2010gestational\u2010age (AGA) preterm infants without BPD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Preterm infants with a gestational age (GA) between 24.0 and 31.6 weeks were studied. The oxygen saturation (SpO<jats:sub>2<\/jats:sub>), fraction to inspired oxygen (FiO<jats:sub>2<\/jats:sub>), and the SpO<jats:sub>2<\/jats:sub> to FiO<jats:sub>2<\/jats:sub> ratio (SFR) were compared between SGA and AGA infants. The association between SGA and SFR at 36 weeks was assessed using a multiple regression analysis. In the subgroup without BPD, SGA were match\u2010paired for GA and gender with AGA infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We analyzed 1189 infants surviving at 36 weeks: 194 (16%) were SGA and 995 (84%) AGA. The incidence of BPD was significantly higher in SGA than AGA infants (32% vs. 13%; <jats:italic>p<\/jats:italic>\u2009=\u2009.000). Out of the 995 infants without BPD, 132 (13%) were SGA and 863 (87%) AGA. SGA was negatively associated with the SFR value at 36 weeks, independently from BPD. SGA infants without BPD had significantly higher (better) SFR at birth, but lower (worse) SpO<jats:sub>2<\/jats:sub> and SFR and from 33 to 36 weeks than their matched AGA counterpart. At 36 weeks, median SpO<jats:sub>2<\/jats:sub> and SFR values were 97.7 versus 98.4 (<jats:italic>p<\/jats:italic>\u2009=\u2009.006) and 465 versus 468 (<jats:italic>p<\/jats:italic>\u2009=\u2009.010) in match\u2010paired SGA and AGA, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among preterm infants of less than 32 weeks and without BPD, SGA infants had a reduced pulmonary oxygen diffusion at 36 weeks in comparison with AGA infants.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26620","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T20:26:00Z","timestamp":1692649560000},"page":"3054-3062","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Reduced pulmonary oxygen diffusion at 36 weeks of postmenstrual age in small\u2010for\u2010gestational\u2010age preterm infants of less than 32 weeks without bronchopulmonary dysplasia"],"prefix":"10.1002","volume":"58","author":[{"given":"Alessio","family":"Correani","sequence":"first","affiliation":[{"name":"Department of Odontostomatologic and Specialized Clinical Sciences Polytechnic University of Marche Ancona Italy"},{"name":"Division of Neonatology, Mother and Child Department G. 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