{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T01:10:15Z","timestamp":1740618615057,"version":"3.38.0"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T00:00:00Z","timestamp":1690934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Airway inflammation starts in early life in cystic fibrosis (CF) and limited, objective markers are available to help identify infants with increased inflammation. We aimed to investigate neutrophil, lymphocyte ratio (NLR), mean platelet volume (MPV) and immunoreactive trypsinogen (IRT) to be a possible inflammatory biomarker for CF in infancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective cohort study in three centers. Between January 2015 and December 2022, children with CF newborn screening (NBS) positivity and diagnosed as CF were included in the study. Correlation analysis were performed with NLR, MPV, IRT and follow\u2010up parameters such as z\u2010scores, modified Shwachman\u2010Kulczycki score (mSKS) at the first, second, third and sixth ages and pulmonary function test (PFT) at the sixth age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 92 children with CF included in the study and 47.8% of them were female. There were no correlations between NLR, MPV and weight and height z\u2010scores for all ages (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05), a negative correlation was found between MPV and body mass indexes (BMI) z\u2010score at the age of 6 (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.443, <jats:italic>p<\/jats:italic>\u2009=\u20090.038). No correlation was found between NLR, MPV and PFT parameters and mSKS at all ages (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). There was a negative correlation between first IRT and BMI z\u2010score at 6 years of age (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.381, <jats:italic>p<\/jats:italic>\u2009=\u20090.046) and negative correlations between second IRT and weight and BMI z\u2010score at the age of 6 (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.462, <jats:italic>p<\/jats:italic>\u2009=\u20090.010; <jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.437, <jats:italic>p<\/jats:italic>\u2009=\u20090.016, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Higher MPV and IRT levels during NBS period are associated with worse nutritional outcome which may reflect chronic inflammation. Children with higher MPV and IRT should be followed up closely in terms of chronic inflammation and nutritional status.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26628","type":"journal-article","created":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T12:41:25Z","timestamp":1690980085000},"page":"3106-3112","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Neutrophil lymphocyte ratio, mean platelet volume, and immunoreactive trypsinogen as early inflammatory biomarkers for cystic fibrosis in infancy: A retrospective cohort study"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7284-4999","authenticated-orcid":false,"given":"Tu\u011fba","family":"\u015ei\u015fmanlar Eyuboglu","sequence":"first","affiliation":[{"name":"Department of Pediatric Pulmonology Gazi University Faculty of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5360-8517","authenticated-orcid":false,"given":"Ayse Tana","family":"Aslan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology Gazi University Faculty of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pelin","family":"Asfuroglu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology Gazi University Faculty of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6185-6686","authenticated-orcid":false,"given":"Nursima","family":"Kunt","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Gazi University Faculty of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Ersoy","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology Erciyes University Faculty of Medicine Kayseri Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3003-918X","authenticated-orcid":false,"given":"Mehmet","family":"Kose","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology Erciyes University Faculty of Medicine Kayseri Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gokcen","family":"Unal","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology Necmettin Erbakan University Meram Medicine Faculty Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8059-902X","authenticated-orcid":false,"given":"Sevgi","family":"Pekcan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology Necmettin Erbakan University Meram Medicine Faculty Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2020.05.015"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3849"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1300109"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2013-203204"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2006.12.001"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.23.2.4214"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200901-0069OC"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.139493"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(16)00053-9"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-017-0713-8"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.4149\/BLL_2021_078"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9213074"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0077420"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2017.12.012"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1012310"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/1817-1737.84778"},{"key":"e_1_2_10_18_1","unstructured":"Sample Size Calculators for designing clinical research. 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