{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:39:02Z","timestamp":1790728742189,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T00:00:00Z","timestamp":1691539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The utility of the forced oscillations technique (FOT) in cystic fibrosis (CF) remains uncertain. The aim of this study was to explore the ability of lower\u2010frequency FOT indices, alone and after adjustment for the lung volume, to assess the extent of ventilation inhomogeneity in CF patients with varying disease severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty\u2010five children, adolescents, and adults with CF (age 6.9\u201327 years) underwent spirometry, FOT, and nitrogen multiple\u2010breath washout (N2\u2010MBW) measurements. The respiratory resistance and reactance at 5\u2009Hz (Rrs5 and Xrs5, respectively) were recorded, and a novel FOT index, the specific respiratory conductance (sGrs), was computed as the reciprocal of Rrs5 divided by the functional residual capacity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The sGrs correlated well with the lung clearance index (LCI) (Spearman's\n                      <jats:italic>r<\/jats:italic>\n                      : \u2013.797), whereas the correlation of Rrs5 and Xrs5 with the LCI, albeit significant, was weaker (\n                      <jats:italic>r<\/jats:italic>\n                      : .643 and \u2013.631, respectively). The sGrs emerged as the most robust predictor of LCI regardless of the severity of lung disease, as reflected by patients' age and lung function measurements. Most importantly, the relationship between sGrs and LCI remained unaffected by lung hyperinflation, as opposed to that of the LCI with the spirometric and standard FOT indices.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In CF patients, the FOT indices at 5\u2009Hz and the novel, volume\u2010adjusted parameter sGrs, reflect the extent of lung involvement and the underlying ventilation inhomogeneity in a way comparable to N2\u2010MBW. Future research should explore the role of lower\u2010frequency FOT in assessing the severity and monitoring the progression of CF lung disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.26635","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T10:06:31Z","timestamp":1691575591000},"page":"3147-3155","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Low\u2010frequency oscillometry indices to assess ventilation inhomogeneity in CF patients"],"prefix":"10.1002","volume":"58","author":[{"given":"Sotirios","family":"Fouzas","sequence":"first","affiliation":[{"name":"Pediatric Respiratory Unit, Pediatric Department University Hospital of Patras Patras Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Kogias","sequence":"additional","affiliation":[{"name":"Pediatric Respiratory and Cystic Fibrosis Unit, 3rd Paediatric Department Aristotle University of Thessaloniki Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Gioulvanidou","sequence":"additional","affiliation":[{"name":"Pediatric Respiratory and Cystic Fibrosis Unit, 3rd Paediatric Department Aristotle University of Thessaloniki Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aris","family":"Bertzouanis","sequence":"additional","affiliation":[{"name":"Pediatric Respiratory Unit, Pediatric Department University Hospital of Patras Patras Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisavet\u2010Anna","family":"Chrysochoou","sequence":"additional","affiliation":[{"name":"Pediatric Respiratory and Cystic Fibrosis Unit, 3rd Paediatric Department Aristotle University of Thessaloniki Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael \u0392.","family":"Anthracopoulos","sequence":"additional","affiliation":[{"name":"Pediatric Respiratory Unit, Pediatric Department University Hospital of Patras Patras Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Tsanakas","sequence":"additional","affiliation":[{"name":"Pediatric Respiratory and Cystic Fibrosis Unit, 3rd Paediatric Department Aristotle University of Thessaloniki Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9505-2054","authenticated-orcid":false,"given":"Elpis","family":"Hatziagorou","sequence":"additional","affiliation":[{"name":"Pediatric Respiratory and Cystic Fibrosis Unit, 3rd Paediatric Department Aristotle University of Thessaloniki Thessaloniki 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