{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T20:51:18Z","timestamp":1768423878573,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T00:00:00Z","timestamp":1692230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The association between viral infections and pulmonary exacerbations in children with cystic fibrosis (cwCF) is well established. However, the question of whether cwCF are at a higher risk of COVID\u201019 or its adverse consequences remains controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted an observational, multicenter, cross\u2010sectional study of cwCF infected by severe acute respiratory syndrome coronavirus\u20102\u00a0(SARS\u2010CoV\u20102) between March 2020 and June 2022, (first\u00a0to sixth\u00a0COVID\u201019 pandemic waves) in Spain. The study aimed to describe patients'\u00a0basal characteristics, SARS\u2010CoV\u20102 clinical manifestations and outcomes, and whether there were differences across the pandemic waves.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During study time, 351 SARS\u2010CoV2 infections were reported among 341 cwCF. Median age was 8.5 years (range 0\u201317) and 51% were female. Cases were unevenly distributed across the pandemic, with most cases (82%) clustered between November 2021 and June 2022 (sixth\u00a0wave, also known as Omicron Wave due to the higher prevalence of this strain in that period in Spain). Most cwCF were asymptomatic (24.8%) or presented with mild Covid\u201019 symptoms (72.9%). Among symptomatic, most prevalent symptoms were fever (62%) and increased cough (53%). Infection occurring along the sixth wave was the only independent risk factor for being symptomatic. Just eight cwCF needed hospital admission. No multisystem inflammatory syndrome, persisting symptoms, long\u2010term sequelae, or deaths were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Spanish current data indicate that cwCF do not experience higher risks of SARS\u2010CoV\u20102 infection nor worse health outcomes or sequelae. Changes in patients'\u00a0basal characteristics, clinical courses, and outcomes were detected across waves. While the pandemic continues, a worldwide monitoring of COVID\u201019 in pediatric CF patients is needed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26644","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T15:07:16Z","timestamp":1692630436000},"page":"3195-3205","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["SARS\u2010CoV\u20102 infection in children with cystic fibrosis: A cross\u2010sectional multicenter study in Spain. 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