{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:36:02Z","timestamp":1793140562020,"version":"4.5.0"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T00:00:00Z","timestamp":1694563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>An increasing number of children with diverse medical conditions are using long\u2010term noninvasive ventilation (NIV). This study examined the impact of demographic, clinical, and technology\u2010related factors on long\u2010term NIV adverse events in a large cohort of children using long\u2010term NIV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a multicenter retrospective review of all children who initiated long\u2010term NIV in the province of Alberta, Canada, from January 2005 to September 2014, and followed until December 2015. Inclusion criteria were children who had used NIV for 3 months or more and had at least one follow\u2010up visit with the NIV programs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 507 children who initiated NIV at a median age of 7.5 (interquartile range: 8.6) years and 93% of them reported at least one NIV\u2010related adverse event during the initial follow\u2010up visit. Skin injury (20%) and unintentional air leaks (19%) were reported more frequently at the initial visit. Gastrointestinal symptoms, midface hypoplasia, increased drooling, aspiration and pneumothorax were rarely reported (&lt;5%). Younger age and underlying conditions such as Down syndrome, achondroplasia, and Duchenne muscular dystrophy were early predictors of unintentional air leak. Younger age also predicted child sleep disruption in the short term and ongoing parental sleep disruption. Obesity was a risk factor for persistent nasal symptoms. Mask type was not a significant predictor for NIV\u2010related short\u2010 or long\u2010term complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study demonstrates that NIV\u2010related complications are frequent. Appropriate mask\u2010fitting and headgear adaptation, and a proactive approach to early detection may help to reduce adverse events.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26689","type":"journal-article","created":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T07:58:40Z","timestamp":1694591920000},"page":"3549-3559","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Predictors of NIV\u2010related adverse events in children using long\u2010term noninvasive ventilation"],"prefix":"10.1002","volume":"58","author":[{"given":"Prabhjot K.","family":"Bedi","sequence":"first","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine and Dentistry, University of Alberta Edmonton AB Canada"},{"name":"Women &amp; Children's Health Research Institute University of Alberta Edmonton AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristie","family":"DeHaan","sequence":"additional","affiliation":[{"name":"Department of Medicine Faculty of Medicine and Dentistry, University of Alberta Edmonton AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2152-6426","authenticated-orcid":false,"given":"Daniel","family":"Ofosu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine and Dentistry, University of Alberta Edmonton AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Olmstead","sequence":"additional","affiliation":[{"name":"Faculty of Nursing University of Alberta Edmonton AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna E.","family":"MacLean","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine and Dentistry, University of Alberta Edmonton AB Canada"},{"name":"Women &amp; Children's Health Research Institute University of Alberta Edmonton AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Castro\u2010Codesal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine and Dentistry, University of Alberta Edmonton AB Canada"},{"name":"Women &amp; Children's Health Research Institute University of Alberta Edmonton AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2017.02.005"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01404-2021"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-1672"},{"issue":"2","key":"e_1_2_11_5_1","article-title":"Non\u2010invasive ventilation for cystic fibrosis","volume":"2","author":"Moran F","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2012-201964"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2016.196"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(16)30151-5"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2019.03.004"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/24745332.2020.1722975"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-005-2669-2"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.12040"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-0910"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-005-2669-2"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1590\/s1806-37562016000000172"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.enfi.2016.12.001"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.2147\/MDER.S121712"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.04036"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2013-305322"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2005.07.002"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-1634"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc10534"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2007.05.005"},{"key":"e_1_2_11_26_1","first-page":"36","article-title":"Midface deformities in children receiving non\u2010invasive ventilation: the extent of the problem. 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