{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T16:57:22Z","timestamp":1771261042748,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Obstructive sleep apnea (OSA) has been associated with pulmonary hypertension (PH) through a complex and bidirectional relationship. The prevalence of OSA and other forms of sleep\u2010disordered breathing (SDB) among children with PH is not well understood. A better understanding could help elucidate contributing factors for PH, guide diagnostic testing, and inform therapies. We therefore determined the proportion of SDB codiagnosis and OSA risk factors among a cohort of children with PH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective chart review was performed for children 0\u221221 years old with PH who underwent polysomnography (PSG) between 1 January\u00a02010 and 31 August\u00a02020. The primary outcome was OSA occurrence and risk based on demographics, diagnoses, and PH classification. The secondary outcome was occurrence and risk of other SDB diagnoses based on PH classification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 89 children identified, diagnoses included OSA (<jats:italic>N<\/jats:italic>\u2009=\u200979, 89%), central sleep apnea (<jats:italic>N<\/jats:italic>\u2009=\u200911, 12%), sleep\u2010related hypoventilation (<jats:italic>N<\/jats:italic>\u2009=\u20096, 7%), and non\u2010apneic hypoxemia (<jats:italic>N<\/jats:italic>\u2009=\u200928, 31%). Trisomy 21 diagnosis (<jats:italic>N<\/jats:italic>\u2009=\u200938, 43%) was associated with increased OSA risk (RR: 1.24, 95% CI: [1.09\u22121.42]) and age &gt;12 months at PSG was associated with decreased OSA risk (<jats:italic>N<\/jats:italic>\u2009=\u200952, 58%, RR: 0.60, 95% CI: [0.45\u22120.81]). There was no difference in SDB risk based on Group 1 (<jats:italic>N<\/jats:italic>\u2009=\u200956, 63%) or Group 3 (<jats:italic>N<\/jats:italic>\u2009=\u200933, 37%) PH and no difference in OSA severity based on demographics and diagnoses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>OSA was diagnosed among a majority of children with PH, and other SDB diagnoses were identified in a significant proportion of children. These findings support routine screening for SDB with PSG\u00a0in children with PH.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26693","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T11:35:25Z","timestamp":1695209725000},"page":"3566-3573","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Occurrence of sleep\u2010disordered breathing in children with pulmonary hypertension"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6960-8143","authenticated-orcid":false,"given":"Daniel","family":"Ignatiuk","sequence":"first","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center, Division of Pulmonary and Sleep Medicine Cincinnati Ohio USA"},{"name":"Department of Pediatrics University of Cincinnati College of Medicine Cincinnati Ohio 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