{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T22:24:02Z","timestamp":1786832642238,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T00:00:00Z","timestamp":1699401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>We performed this study aiming to evaluate changes in epidemiology, clinical presentation and outcomes of children hospitalized for viral lower respiratory tract infections (LRTI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective study of children younger than 18 years of age hospitalized for LRTIs with a positive respiratory viral testing from 2018 to 2022. We compared need of pediatric intensive care unit (PICU), invasive ventilation, and other respiratory support, viral etiologies, clinical presentations, imaging, and laboratory results in the precovid (2018\u20132019) and covid (2020\u20132022) period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 523 were included in the analysis. In the pandemic period, the detection of influenza was 95% less likely to occur (odds ratio [OR]: 0.05; 95% confidence interval [95% CI]: 0.02\u20130.12; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), likewise the detection of adenovirus was 77% less likely to occur (OR: 0.23; 95% CI: 0.10\u20130.51; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). In the pandemic period, the number of codetections increased from 15.52% in 2018 to 57.25% in 2022, resulting in a significantly increasing trend (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). The odds of transfer to PICU was more than five times greater during the pandemic period (OR: 5.31; 95% CI: 1.78\u201315.86; <jats:italic>p<\/jats:italic>\u2009=\u2009.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We found that the pattern of LRTI in children during COVID\u201019 pandemic significantly changed in terms of etiologies and increased severity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26755","type":"journal-article","created":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T13:20:27Z","timestamp":1699449627000},"page":"362-370","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Changes in clinical, demographic, and outcome patterns of children hospitalized with non\u2010SARS\u2010CoV\u20102 viral low respiratory tract infections before and during the COVID pandemic in Rome, Italy"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8567-2639","authenticated-orcid":false,"given":"Danilo","family":"Buonsenso","sequence":"first","affiliation":[{"name":"Department of Woman and Child Health Fondazione Policlinico Universitario A. Gemelli IRCCS Rome Italy"},{"name":"Centro di Salute Globale Universit\u00e0 Cattolica del Sacro Cuore Roma Italia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0401-9767","authenticated-orcid":false,"given":"Valentina","family":"Ferro","sequence":"additional","affiliation":[{"name":"Department of Emergency, Acceptance and General Pediatrics Bambino Ges\u00f9 Children's Hospital, IRCCS Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6999-0172","authenticated-orcid":false,"given":"Francesca","family":"Viozzi","sequence":"additional","affiliation":[{"name":"Medicine and Surgery Universit\u00e0 Cattolica del Sacro Cuore Roma Italia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Morello","sequence":"additional","affiliation":[{"name":"Department of Woman and Child Health Fondazione Policlinico Universitario A. Gemelli IRCCS Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Proli","sequence":"additional","affiliation":[{"name":"Department of Woman and Child Health Fondazione Policlinico Universitario A. Gemelli IRCCS Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Bersani","sequence":"additional","affiliation":[{"name":"Department of Woman and Child Health Fondazione Policlinico Universitario A. Gemelli IRCCS Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Lazzareschi","sequence":"additional","affiliation":[{"name":"Department of Woman and Child Health Fondazione Policlinico Universitario A. 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