{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T01:26:31Z","timestamp":1786238791157,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T00:00:00Z","timestamp":1700179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Neonates with persistent pulmonary hypertension of the newborn (PPHN) can present with hypoxia and right ventricular dysfunction with resultant inadequate oxygen delivery and end\u2010organ damage. This study describes the use of prostaglandin\u2010E1 (PGE) for ductal patency to preserve right ventricular systolic function and limit afterload in newborns with PPHN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a retrospective cohort study that follows the hemodynamics, markers of end\u2010organ perfusion, length of therapeutics, and echocardiographic variables of 57 newborns who used prostglandin\u2010E1 in the setting of PPHN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Tachycardia, lactic acidosis, and supplemental oxygen use improved following PGE initiation. Fractional area change (FAC), to assess right ventricular systolic function, and pulmonary arterial acceleration time indexed to right ventricular ejection time (PAAT\/RVET), to assess right ventricular afterload, also improved over three time points relative to PGE use (before, during, and after).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overall, we described the safety and utility of PGE in newborns with severe PPHN for stabilization while allowing natural disease progression.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26759","type":"journal-article","created":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T03:38:14Z","timestamp":1700278694000},"page":"379-388","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prostaglandin\u2010E1 infusion in persistent pulmonary hypertension of the newborn"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0115-5843","authenticated-orcid":false,"given":"Stephanie M.","family":"Tsoi","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Critical Care Medicine University of California San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hythem","family":"Nawaytou","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology University of California\u00a0San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Almeneisi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology University of California\u00a0San Francisco San Francisco California 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