{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T11:14:04Z","timestamp":1770290044305,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:00:00Z","timestamp":1701129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Rationale<\/jats:title><jats:p>Experimental studies and epidemiological data in adults suggest that somatomedin\u2010C (insulin\u2010like growth factor\u20101, IGF\u20101) may play a role in asthma by modulating airway inflammation, bronchial hyperreactivity, and airway smooth muscle hyperplasia. However, its role in children with asthma is not well understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We established a birth cohort with 339 Chilean pregnant mothers enrolled at the time of delivery from December 2014 to January 2016. We obtained cord blood at birth and followed the offspring every 6 months until 30 months of age, recording data on atopy, wheezing, and other respiratory illnesses. We measured IGF\u20101 in cord blood and determined the Asthma Predictive Index (API) at 30 months. The cohort was divided according to the API.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Complete data were available for 307\/339 (91%) dyads, including 44 preschoolers with API+ and 263 with API\u2013. Demographic characteristics were similar between groups, but mothers of API+ children had a higher prevalence of obesity, previous use of oral contraceptives, and higher education than those of API\u2013 children. API+ children had higher birth weight and significantly higher IGF\u20101 in cord blood (37.4\u2009\u00b1\u200913.2 in API+ vs. 30.5\u2009\u00b1\u200913.0\u2009ng\/ml in API\u2013, <jats:italic>p<\/jats:italic>\u2009=\u2009.01). In the multivariable analysis, IGF\u20101 in cord blood remained independently associated with a higher risk of asthma (adjusted OR for API+ per ng\/ml higher IGF\u20101\u2009=\u20091.03 [1.0\u20131.06], <jats:italic>p<\/jats:italic>\u2009=\u2009.015).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Higher insulin\u2010like growth factor\u20101 in cord blood is associated with asthma risk in the preschool years.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26780","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T13:02:23Z","timestamp":1701176543000},"page":"482-487","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Higher levels of insulin\u2010like growth factor\u20101 in cord blood associate with risk of asthma at age 3"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0708-4281","authenticated-orcid":false,"given":"Jose A.","family":"Castro\u2010Rodriguez","sequence":"first","affiliation":[{"name":"Department of Pediatric Pulmonology, School of Medicine Pontificia Universidad Cat\u00f3lica De Chile Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oslando","family":"Padilla","sequence":"additional","affiliation":[{"name":"Department of Public Health, School of Medicine Pontificia Universidad Cat\u00f3lica De Chile Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Casanello","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Neonatology, School of Medicine Pontificia Universidad Cat\u00f3lica De Chile Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6497-9885","authenticated-orcid":false,"given":"Erick","family":"Forno","sequence":"additional","affiliation":[{"name":"Pulmonary, Allergy, and Sleep Medicine Riley Children's Hospital and Indiana University Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/mp.54.5.311"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-015-0762-z"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.86.2.125"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11523-017-0514-5"},{"key":"e_1_2_10_6_1","first-page":"1","article-title":"Insulin\u2010like growth factor\u20101 signaling in lung development and inflammatory lung diseases","volume":"2018","author":"Wang 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