{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T14:20:24Z","timestamp":1793110824019,"version":"4.5.0"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:00:00Z","timestamp":1701129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To date, different severity scores and indices are available to predict outcome in infants with a congenital diaphragmatic hernia (CDH). The Oxygenation Index (OI) and the Vasoactive\u2010Inotropic Score (VIS) has already been evaluated in the CDH population. The Vasoactive\u2010Ventilation\u2010Renal (VVR) Score was recently evaluated as new severity score in several studies on infants with need for cardiac surgery. The score was shown to outperform the VIS and OI as outcome predictors in these infants, but no data are available regarding the evaluation of the VVR Score in CDH infants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>This was a retrospective single\u2010center analysis at the University Children's Hospital, Bonn, Germany, during the study period from January 2019 until December 2022. Of 108 CDH infants treated at our institution, a final cohort of 100 neonates met the inclusion criteria. Inclusion criteria: diagnosis of CDH (right\u2010sided, left\u2010sided, or bilateral). Exclusion criteria: early mortality (before surgical correction of the diaphragm), palliative care after birth, no available data for OI, VIS, and VVR Score calculation. The OI, the VIS, and the VVR Score were calculated at three selected timepoints: at 48\u201372\u2009h after birth (T1), before surgery (T2), and after surgery (T3).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Results<\/jats:title>\n                    <jats:p>\n                      The primary clinical endpoint (in\u2010hospital mortality) was reached in 21% of the infants. Infants surviving to discharge were allocated to group A, infants with fatal outcome to group B. In the univariate analysis, the OI was significantly higher in infants allocated to group B at T2 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001), and T3 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001). The VIS was significantly higher only at T1 in infants allocated to group B (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.001). The VVR Score was significantly higher at T1 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.017), and at T3 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.002) in infants not surviving to discharge. In the multivariate analysis, the OI at T2\u2009+\u2009T3 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001), the VIS at T1 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.048), and the VVR Score at T1\u2009+\u2009T3 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.023, and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.048, respectively) remained significantly associated with in\u2010hospital mortality. The OI presented the highest area under the curve (AUC) at T2 and T3 (T2:0.867,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.001; T3:0.833,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.000) regarding the primary endpoint in the overall cohort. In the subgroup of infants without need for extracorporeal membrane oxygenation (ECMO) therapy (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200960) the VVR Sore presented the best performance with an AUC of 0.942 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.000) at T3.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The severity scores OI, VIS, and VVR\u2010Score are independent predictors of in\u2010hospital mortality in CDH infants. The OI seems to outperform the VIS and VVR\u2010Score as outcome predictor immediately before and after CDH surgery, whereas the VVR Score presented the best performance in the subgroup of CDH infants without need for ECMO and mild\u2010to\u2010moderate CDH defects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.26785","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T08:49:37Z","timestamp":1701161377000},"page":"574-583","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A comparative analysis of the Vasoactive\u2010Inotropic Score, the Vasoactive\u2010Ventilation\u2010Renal Score, and the Oxygenation Index as outcome predictors in infants with a congenital diaphragmatic hernia"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6501-2243","authenticated-orcid":false,"given":"Lukas","family":"Schroeder","sequence":"first","affiliation":[{"name":"Department of Neonatology and Pediatric Intensive Care Medicine University Children's Hospital Bonn Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Pommer","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Pediatric Intensive Care Medicine University Children's Hospital Bonn Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annegret","family":"Geipel","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Prenatal Medicine University Hospital Bonn Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Strizek","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Prenatal Medicine University Hospital Bonn Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Heydweiller","sequence":"additional","affiliation":[{"name":"Department for Pediatric Surgery, Clinic and Polyclinic for General, Visceral, Thoracic, and Vascular Surgery University Hospital Bonn Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Kipfmueller","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Pediatric Intensive Care Medicine University Children's Hospital Bonn Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Mueller","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Pediatric Intensive Care Medicine University Children's Hospital Bonn Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2014-306174"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201904-0731OC"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2022.101383"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1393960"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2017.12.023"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2012.07.039"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12893-023-01970-3"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2023.1101546"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e3181b806fc"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2023.1086626"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivu409"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2015.11.006"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-022-02130-8"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000444210"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000001694"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.769932"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000512966"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6207"}],"container-title":["Pediatric 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