{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:29:12Z","timestamp":1791566952654,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:00:00Z","timestamp":1701129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cystic fibrosis (CF) is a genetic disease that causes progressive lung disease with major impact on the quality of life. Lung ultrasound (LUS) allows to assess the lung involvement through the artefacts analysis and is increasingly used in children but is not yet used to monitor people with CF(pwCF). The main aim of this study was to describe the LUS pattern of pwCF during their routinary check\u2010up visit. The secondary objective was to correlate the LUS findings with pulmonary function indices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a cross\u2010sectional observational study, enrolling adolescents and young adults with CF. Each patient underwent clinical assessment, measurement of SpO2, assessment of lung function by spirometry and LUS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010nine subjects with CF were included. The most frequent alterations were consolidations (72.4%) located in the left apical anterior and right apical posterior regions followed by interstitial syndrome (65.5%). The 41.4% of cases presented the lingula involvement, characterized by a consolidation with static air bronchogram, and 55.2% showed pleural irregularity mainly in the posterior apical regions. A significant correlation was found between the LUS total score and spirometric indices: FEV<jats:sub>1<\/jats:sub> (<jats:italic>p<\/jats:italic>\u2009=\u2009.003), FVC (<jats:italic>p<\/jats:italic>\u2009=\u2009.002), Tiffenau Index &lt;80% (<jats:italic>p<\/jats:italic>\u2009=\u2009.014), and FEF 25\u201375 (<jats:italic>p<\/jats:italic>\u2009=\u2009.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study describes LUS findings in pwCF. It also showed a correlation between LUS score and the patients' lung function measured by spirometric indices. We conclude that LUS may be useful in routine monitoring of pwCF in combination with clinical and spirometric assessment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26787","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T10:09:24Z","timestamp":1701166164000},"page":"592-599","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Lung ultrasound evaluation in people with cystic fibrosis: A new approach in the pulmonology outpatient clinic"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2430-9876","authenticated-orcid":false,"given":"Antonietta","family":"Curatola","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Fondazione Policlinico Universitario \u201cA. Gemelli\u201d IRCCS Universit\u00e0 Cattolica del Sacro Cuore Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Corona","sequence":"additional","affiliation":[{"name":"University of Trieste Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenica","family":"Squillaci","sequence":"additional","affiliation":[{"name":"University of Trieste Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Saccari","sequence":"additional","affiliation":[{"name":"Institute of Maternal and Child Health \u2013 IRCCS Burlo Garofolo Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Chiaretti","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Fondazione Policlinico Universitario \u201cA. Gemelli\u201d IRCCS Universit\u00e0 Cattolica del Sacro Cuore Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Egidio","family":"Barbi","sequence":"additional","affiliation":[{"name":"University of Trieste Trieste Italy"},{"name":"Institute of Maternal and Child Health \u2013 IRCCS Burlo Garofolo Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Maschio","sequence":"additional","affiliation":[{"name":"Institute of Maternal and Child Health \u2013 IRCCS Burlo Garofolo Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.01137.x"},{"issue":"4","key":"e_1_2_9_3_1","first-page":"1","article-title":"Italian Cystic Fibrosis Registry (ICFR). Report 2019\u20102020","volume":"46","author":"Campagna G","year":"2022","journal-title":"Epidemiol Prev"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2018.06.48"},{"key":"e_1_2_9_5_1","first-page":"e0215786","volume-title":"PLoS ONE","author":"Strzelczuk\u2013Judka L","year":"2019"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24125"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1590\/1806-3713\/e20190128"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-104936"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2013.09.003"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2019192194"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11101783"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.07038"},{"issue":"60","key":"e_1_2_9_13_1","first-page":"1261","article-title":"How useful is the lung ultrasound in cystic fibrosis?","volume":"48","author":"Ciuca I","year":"2016","journal-title":"Eur Respir J"},{"key":"e_1_2_9_14_1","first-page":"A163","article-title":"P115 Unwarranted Use of Nephrotoxic Antibiotics in Children with Cystic Fibrosis","volume":"73","author":"Ditchfield N","year":"2018","journal-title":"Thorax"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-021-01728-8"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-012-2513-4"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-019-05725-8"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-020-04750-w"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24362"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.104150"},{"key":"e_1_2_9_21_1","article-title":"The value of lung ultrasound to detect the early pleural and pulmonary pathologies in nonhospitalized COVID \u201019\u2010suspected cases in a population with a low prevalence of COVID \u201019 infection: a prospective study in 297 subjects","author":"Safai Zadeh E","year":"2021","journal-title":"J Ultrasound Med"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9260(99)90847-4"},{"key":"e_1_2_9_23_1","first-page":"28","article-title":"Reflected ultrasound in the study of diseases of the chest","volume":"78","author":"Joyner CR Jr","year":"1967","journal-title":"Trans Am Clin Climatol Assoc"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/5584_2018_202"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1590\/1806-9282.60.03.009"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-020-00388-8"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10214884"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.26787","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T12:41:34Z","timestamp":1710420094000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.26787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,28]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/ppul.26787"],"URL":"https:\/\/doi.org\/10.1002\/ppul.26787","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,28]]},"assertion":[{"value":"2022-03-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}