{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:43:41Z","timestamp":1792089821119,"version":"4.4.0"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:00:00Z","timestamp":1704931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>For patients with a congenital diaphragmatic hernia, conventional mechanical ventilation (CMV) and high\u2010frequency oscillatory ventilation (HFOV) are used in initial ventilatory management. HFOV has recently been recommended as a rescue therapy; however, we use HFOV for initial ventilation management, with a preoperative challenge test for CMV conversion and respiratory function testing at the time of CMV conversion. We aimed to compare patient characteristics between CMV conversion\u2010 and HFOV\u2010preferred treatment groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ventilator settings and blood gases were retrospectively evaluated pre\u2010 and post\u2010CMV conversion, and respiratory function tests for compliance of the respiratory system (Crs) and for resistance of the respiratory system (Rrs) were performed during the trial to CMV conversion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No differences were observed between the CMV conversion\u2010 and HFOV\u2010preferred groups regarding gestational age, birth weight, and observed\/expected lung area\u2010to\u2010head circumference ratios. The median Crs (ml\/cmH<jats:sub>2<\/jats:sub>O\/kg) and Rrs (cmH<jats:sub>2<\/jats:sub>O\uff65kg\/L\/s) in the CMV conversion\u2010 and HFOV\u2010preferred groups was 0.42 versus 0.53 (<jats:italic>p<\/jats:italic>\u2009=\u2009.44) and 467 versus 327 (<jats:italic>p<\/jats:italic>\u2009=\u2009.045), respectively. The pre and posttrial amount of change in blood gas levels and ventilator parameters in the CMV conversion\u2010 and HFOV\u2010preferred groups were as follows: mean airway pressure, \u22122.0 versus 0\u2009cmH<jats:sub>2<\/jats:sub>O; partial pressure of carbon dioxide, 6.1 versus 2.9\u2009Torr; alveolar\u2010arterial oxygen difference, \u221239.5 versus \u221250 Torr; and oxygenation index, \u22121.0 versus \u22120.6; respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Respiratory function tests were useful in tailoring ventilator settings. Patients with high Rrs values responded better to CMV conversion.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26789","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T14:00:39Z","timestamp":1704981639000},"page":"609-616","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Respiratory function testing for guiding ventilator mode conversion in congenital diaphragmatic hernia"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3103-1750","authenticated-orcid":false,"given":"Sasagu","family":"Kimura","sequence":"first","affiliation":[{"name":"Department of Neonatology Kanagawa Children's Medical Center Yokohama Japan"},{"name":"Department of Neonatology Yamaguchi Prefectural Grand Medical Center Hofu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuaki","family":"Toyoshima","sequence":"additional","affiliation":[{"name":"Department of Neonatology Kanagawa Children's Medical Center Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8490-475X","authenticated-orcid":false,"given":"Tomoyuki","family":"Shimokaze","sequence":"additional","affiliation":[{"name":"Department of Neonatology Kanagawa Children's Medical Center Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaoru","family":"Katsumata","sequence":"additional","affiliation":[{"name":"Department of Neonatology Kanagawa Children's Medical Center Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Neonatology Kanagawa Children's Medical Center Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikuo","family":"Hoshino","sequence":"additional","affiliation":[{"name":"Department of Neonatology Kanagawa Children's Medical Center Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5376"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8892"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.12922"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2015.09.010"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001533"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.808317"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000444210"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3233\/NPM-1813"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2007.04.015"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-020-00833-6"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-020-02258-8"},{"key":"e_1_2_9_13_1","first-page":"41","article-title":"Pulmonary function test in infants","volume":"5","author":"Hasegawa H","year":"1993","journal-title":"Nihon Mijyukuji Shinseiji Gakkai Zashi"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(87)80475-4"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.4047133"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1590\/s0102-865020180100000002"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.61.12.1178"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211830"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40748-017-0045-1"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(87)80354-2"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.26789","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T12:41:20Z","timestamp":1710420080000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.26789"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,11]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/ppul.26789"],"URL":"https:\/\/doi.org\/10.1002\/ppul.26789","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,11]]},"assertion":[{"value":"2023-06-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}