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We hypothesized that serum lipids and vitamin levels would increase with CFTR modulator therapy and that greater increase in lipids and vitamin levels would be related to greater increase in BMI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study was performed to evaluate the impact of elexacaftor\/tezacaftor\/ivacaftor (ETI) on nutritional parameters, serum lipids, and fat\u2010soluble vitamin levels. Pre\u2010ETI values (&lt;2 years prior) and post\u2010ETI values (&gt;1 month after) were compared. Linear regression was used to evaluate whether change in BMI is associated with the change in lipid and\/or vitamin levels and whether modulator duration is associated with the degree of rise in lipid and\/or vitamin levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Adults and adolescents with CF (<jats:italic>n<\/jats:italic>\u2009=\u2009137) were evaluated before and 31\u2013300 days after starting ETI. Median BMI (adults 21.9 vs. 23.5\u2009kg\/m<jats:sup>2<\/jats:sup>; adolescents 48 vs. 63 percentile) increased after initiation of ETI. Total cholesterol (126 vs. 154\u2009mg\/dL), low\u2010density lipoprotein cholesterol (63 vs. 78\u2009mg\/dL), non\u2010high\u2010density lipoprotein cholesterol (84 vs. 102\u2009mg\/dL), and high density lipoprotein cholesterol (43 vs. 49\u2009mg\/dL) increased after ETI, while triglycerides and very low density lipoprotein did not change. Median values for vitamin D (34.5 vs. 38.0\u2009ng\/mL) and vitamin A (40.1 vs. 47.9 \u00b5g\/dL) increased, while vitamin E did not change significantly. There was no significant correlation between BMI change or duration of modulator therapy with vitamin levels or lipid changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>After initiation of ETI therapy, serum lipids increased in our population, but most values remained within the normal range. Vitamins A and D levels increased post\u2010ETI and no changes were noted in vitamin E. No significant correlation between the degree of BMI change and the magnitude of increase in lipids or vitamin levels was found.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26823","type":"journal-article","created":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T10:38:53Z","timestamp":1704451133000},"page":"734-742","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Impact of elexacaftor\/tezacaftor\/ivacaftor on lipid and fat\u2010soluble vitamin levels and association with body mass index"],"prefix":"10.1002","volume":"59","author":[{"given":"Tanvi","family":"Patel","sequence":"first","affiliation":[{"name":"Case Western Reserve University School of Medicine Cleveland Ohio USA"},{"name":"Loyola University School of Medicine Maywood Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9642-3814","authenticated-orcid":false,"given":"Kimberly","family":"McBennett","sequence":"additional","affiliation":[{"name":"Case Western Reserve University School of Medicine Cleveland Ohio USA"},{"name":"University Hospitals Cleveland Medical Center Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3094-9703","authenticated-orcid":false,"given":"Senthilkumar","family":"Sankararaman","sequence":"additional","affiliation":[{"name":"Case Western Reserve University School of Medicine Cleveland Ohio USA"},{"name":"University Hospitals Cleveland Medical Center Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Schindler","sequence":"additional","affiliation":[{"name":"Case Western Reserve University School of Medicine Cleveland Ohio USA"},{"name":"University Hospitals Cleveland Medical Center Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krithika","family":"Sundaram","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nori Mercuri","family":"Minich","sequence":"additional","affiliation":[{"name":"Case Western Reserve University School of Medicine Cleveland Ohio USA"},{"name":"University Hospitals Cleveland Medical Center Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sindhoosha","family":"Malay","sequence":"additional","affiliation":[{"name":"University Hospitals Cleveland Medical Center Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2573-2131","authenticated-orcid":false,"given":"Katherine","family":"Kutney","sequence":"additional","affiliation":[{"name":"Case Western Reserve University School of Medicine Cleveland Ohio USA"},{"name":"University Hospitals Cleveland Medical Center Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.25733"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4634"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/75.6.1005"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14061216"},{"issue":"19","key":"e_1_2_8_6_1","first-page":"6","article-title":"Efficacy and safety of the elexacaftor plus tezacaftor plus ivacaftor combination regimen in people with cystic fibrosis homozygous for the F508del mutation: a double\u2010blind, randomised, phase 3 trial","volume":"6736","author":"Heijerman HGM","year":"2019","journal-title":"Lancet"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1908639"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.05.018"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2023.06.002"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.26243"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.26388"},{"key":"e_1_2_8_12_1","unstructured":"Cystic Fibrosis Foundation Patient Registry. 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