{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:44:54Z","timestamp":1791247494217,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T00:00:00Z","timestamp":1703030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Respiratory syncytial virus (RSV) causes not only infantile recurrent wheezing but also the development of asthma. To investigate whether palivizumab, an anti\u2010RSV monoclonal antibody, prophylaxis given to preterm infants during the first RSV season reduces the incidence of subsequent recurrent wheezing and\/or development of asthma, at 10 years of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted an observational prospective multicenter (52 registered hospitals in Japan) case\u2010control study in preterm infants with a gestational age between 33 and 35 weeks followed for 6 years. During the 2007\u22122008 RSV season, the decision to administer palivizumab was made based on standard medical practice (SCELIA study). Here, we followed these subjects until 10 years of age. Parents of study subjects reported the patients' physician's assessment of recurrent wheezing\/asthma, using a report card and a novel mobile phone\u2010based reporting system using the internet. The relationship between RSV infection and asthma development, as well as the relationship between other factors and asthma development, were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 154 preterm infants enrolled, 113 received palivizumab during the first year of life. At 10 years, although both recurrent wheezing and development of asthma were not significantly different between the treated and untreated groups, maternal smoking with aeroallergen sensitization of the patients was significantly correlated with physician\u2010diagnosed asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In contrast to the prior study results at 6 years, by 10 years palivizumab prophylaxis had no impact on recurrent wheezing or asthma, but there was a significant correlation between maternal passive smoking with aeroallergen sensitization and development of asthma by 10 years of age.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26824","type":"journal-article","created":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T12:26:11Z","timestamp":1703075171000},"page":"743-749","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Palivizumab prophylaxis in preterm infants and subsequent wheezing\/asthma: 10\u2010year follow\u2010up study"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8815-8552","authenticated-orcid":false,"given":"Masahiko","family":"Kato","sequence":"first","affiliation":[{"name":"Department of Pediatrics Tokai University School of Medicine Isehara Japan"},{"name":"Department of Pediatrics Tokai University Hachioji Hospital Hachioji Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5273-1820","authenticated-orcid":false,"given":"Hiroyuki","family":"Mochizuki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tokai University School of Medicine Isehara Japan"},{"name":"Department of Pediatrics Tokai University Hachioji Hospital Hachioji Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9294-9429","authenticated-orcid":false,"given":"Yuichi","family":"Kama","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tokai University School of Medicine Isehara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Kusuda","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kyorin University Mitaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Oral &amp; Medical Management, Section of Pediatrics Fukuoka Dental College Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigemi","family":"Yoshihara","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Dokkyo Medical University Mibu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Furuya","sequence":"additional","affiliation":[{"name":"Department of Basic Clinical Science and Public Health Tokai University School of Medicine Isehara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric A. F.","family":"Sim\u00f5es","sequence":"additional","affiliation":[{"name":"Colorado School of Public Health University of Colorado School of Medicine and Center for Global Health Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Scientific Committee for Elucidation of Infantile Asthma (SCELIA)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,20]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201810-1931CI"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e31823b66b8"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.88.12.1086"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000455140"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000244"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)10321-5"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.5.9906076"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000122604.32137.29"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200406-730OC"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2009.121582"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/514115"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e318220a553"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.102.3.531"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.02.032"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.05.026"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1211917"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-0982"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201609-1812OC"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.95.08030483"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(18)30055-9"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30109-0"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0125422"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40121-017-0151-4"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.75.5.392"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-016-3029-6"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-30304-9"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.06.015"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200510-1552OC"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2012.02201.x"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13670"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17145087"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1153"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.07.017"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.26824","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T12:41:12Z","timestamp":1710420072000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.26824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,20]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/ppul.26824"],"URL":"https:\/\/doi.org\/10.1002\/ppul.26824","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,20]]},"assertion":[{"value":"2023-07-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}