{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:10:24Z","timestamp":1781583024502,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T00:00:00Z","timestamp":1703548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Less\u2010invasive surfactant administration (LISA) is widely used for surfactant delivery to spontaneously breathing preterm infants on nasal CPAP. However, the use of analgesia and\/or sedation for the LISA procedure remains controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a cross\u2010sectional survey of all tertiary neonatal intensive care units (NICUs) in Austria, Germany, and Switzerland to assess current practices of analgosedation for LISA in preterm infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010eight of 172 (51.2%) NICUs responded to the survey, of which 83 (94.3%) perform LISA. Analgosedation for LISA is used in 60 (72.3%) NICUs. Twenty\u2010eight of those (46.7%) have unit protocols to guide analgosedation while 32 (53.3%) administer medication at the discretion of the attending physician. Ketamine (45.0% of NICUs), propofol (41.7%), fentanyl (21.7%), morphine (20.0%), and midazolam (20.0%) were most frequently used for analgosedation for LISA. Nine (10.7%) NICUs reported the use of pain or distress scores during LISA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>LISA is well established among tertiary NICUs in the German\u2010speaking countries. However, there are considerable variations regarding the use of analgosedation. More evidence is required to guide clinicians seeking to safely and effectively deliver surfactant via a thin catheter to spontaneously breathing preterm infants.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26826","type":"journal-article","created":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T12:59:00Z","timestamp":1703595540000},"page":"750-757","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Analgosedation for less\u2010invasive surfactant administration: Variations in practice"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8661-9645","authenticated-orcid":false,"given":"Tobias","family":"Muehlbacher","sequence":"first","affiliation":[{"name":"Newborn Research, Department of Neonatology University Hospital and University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6895-4861","authenticated-orcid":false,"given":"Vinzenz","family":"Boos","sequence":"additional","affiliation":[{"name":"Newborn Research, Department of Neonatology University Hospital and University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonie\u2010Beatrice","family":"Geiger","sequence":"additional","affiliation":[{"name":"Newborn Research, Department of Neonatology University Hospital and University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1496-2625","authenticated-orcid":false,"given":"Christoph M.","family":"R\u00fcegger","sequence":"additional","affiliation":[{"name":"Newborn Research, Department of Neonatology University Hospital and University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beate","family":"Grass","sequence":"additional","affiliation":[{"name":"Newborn Research, Department of Neonatology University Hospital and University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2014.1148"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2006.02126.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2010.192518"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60986-0"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2018-316557"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.10708"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2020-319763"},{"issue":"5","key":"e_1_2_11_9_1","article-title":"Surfactant therapy via thin catheter in preterm infants with or at risk of respiratory distress syndrome","volume":"2021","author":"Abdel\u2010Latif ME","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-016-2812-9"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.13694"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.14995"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.14606"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-020-00878-7"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000518396"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000528914"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000502610"},{"issue":"4","key":"e_1_2_11_18_1","first-page":"F378","article-title":"Sedation during minimal invasive surfactant therapy: a randomised controlled trial","volume":"104","author":"Dekker J","year":"2018","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmac019"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000521553"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-022-02121-9"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-021-06737-1"},{"issue":"7","key":"e_1_2_11_23_1","article-title":"Sucrose for analgesia in newborn infants undergoing painful procedures","volume":"2017","author":"Stevens B","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"issue":"6","key":"e_1_2_11_24_1","article-title":"Non\u2010pharmacological management of infant and young child procedural pain","volume":"2023","author":"Pillai Riddell RR","year":"2023","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000519283"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-4271"},{"key":"e_1_2_11_27_1","unstructured":"NCT05065424.ClinicalTrials.gov"},{"key":"e_1_2_11_28_1","unstructured":"NCT04409665.ClinicalTrials.gov"},{"key":"e_1_2_11_29_1","unstructured":"NCT03735563.ClinicalTrials.gov"},{"key":"e_1_2_11_30_1","unstructured":"NCT04016246.ClinicalTrials.gov"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.26826","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T12:39:35Z","timestamp":1710419975000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.26826"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,26]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/ppul.26826"],"URL":"https:\/\/doi.org\/10.1002\/ppul.26826","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,26]]},"assertion":[{"value":"2023-10-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}