{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:53:48Z","timestamp":1791726828164,"version":"4.3.4"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Ventilator\u2010associated pneumonia (VAP) is a common healthcare\u2010associated infection in pediatric intensive care unit (PICU), increasing mortality, antibiotics use and duration of ventilation and hospitalization. VAP diagnosis is based on clinical and chest X\u2010ray (CXR) signs defined by the 2018 Center for Disease Control (gold standard). However, CXR induces repetitive patients'\u00a0irradiation and technical limitations. This study aimed to investigate if lung ultrasound (LUS) can substitute CXR in the VAP diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A monocentric and prospective study was conducted in a French tertiary care hospital. Patients under 18\u2010year\u2010old admitted to PICU between November 2018 and July 2020 with invasive mechanical ventilation for more than 48\u2009h were included. The studied LUS signs were consolidations, dynamic air bronchogram, subpleural consolidations (SPC), B\u2010lines, and pleural effusion. The diagnostic values of each sign associated with clinical signs (cCDC) were compared to the gold standard approach. LUS, chest X\u2010ray, and clinical score were performed daily.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010seven patients were included. The median age was 8 [3\u201334] months. Nineteen (33%) children developed a VAP. In patients with VAP, B\u2010Lines, and consolidations were highly frequent (100\u00a0and 68.8%) and, associated with cCDC, were highly sensitive (100 [79\u2013100] % and 88 [62\u201398] %, respectively) and specific (95.5 [92\u201398] % and 98 [95\u201399] %, respectively). Other studied signs, including SPC, showed high specificity (&gt;97%) but low sensibility (&lt;50%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>LUS seems to be a powerful tool for VAP diagnosis in children with a clinical suspicion, efficiently substituting CXR, and limiting children's exposure to ionizing radiations.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26827","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T11:12:54Z","timestamp":1703243574000},"page":"758-765","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Lung ultrasound: A potential tool in the diagnosis of ventilator\u2010associated pneumonia in pediatric intensive care units"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8138-6790","authenticated-orcid":false,"given":"Justine","family":"Uguen","sequence":"first","affiliation":[{"name":"Paediatric Intensive Care Unit University Hospital Center F\u00e9lix Guyon La R\u00e9union France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Bouscaren","sequence":"additional","affiliation":[{"name":"Public Health Department, Inserm CIC 1410 University Hospital Center Saint Pierre La R\u00e9union France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00eblle","family":"Pastural","sequence":"additional","affiliation":[{"name":"Paediatric Radiology Department University Hospital Center F\u00e9lix Guyon La R\u00e9union France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Darrieux","sequence":"additional","affiliation":[{"name":"Paediatric Intensive Care Unit University Hospital Center F\u00e9lix Guyon La R\u00e9union France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Aur\u00e9lie","family":"Lopes","sequence":"additional","affiliation":[{"name":"Paediatric Emergency Department, University Hospital Robert\u2010Debre Sorbonne University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael","family":"Levy","sequence":"additional","affiliation":[{"name":"Paediatric Intensive Care Unit University Hospital Center F\u00e9lix Guyon La R\u00e9union France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise","family":"Peipoch","sequence":"additional","affiliation":[{"name":"Paediatric Intensive Care Unit University Hospital Center F\u00e9lix Guyon La R\u00e9union France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/501755"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/2047-2994-3-30"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e318238b260"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-1211"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00041-06"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001340051288"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.2217\/fmb-2018-0108"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.2.8306025"},{"key":"e_1_2_12_10_1","unstructured":"National Healthcare Safety Network.Pneumonia (Ventilator-associated [VAP] and non-ventilatorassociated Pneumonia [PNEU]) Event. 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