{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:15:54Z","timestamp":1740104154223,"version":"3.37.3"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T00:00:00Z","timestamp":1704412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005342","name":"Stichting Vrienden Beatrix Kinderziekenhuis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005342","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The introduction of modulator therapy for cystic fibrosis (CF) has led to an increased interest in the detection of small airway disease (SAD) as sensitive marker of treatment response. The particles in exhaled air (PExA) method, which records exhaled particle mass (PEx ng\/L) and number (PExNR), detects SAD in adult patients. Our primary aim was to investigate if PExA outcomes in children with CF are different when compared to controls and associated with more severe disease. Secondary aims were to assess feasibility and repeatability of PExA in children with CF and to correlate PExA to multiple breath nitrogen washout (MBNW) as an established marker of SAD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirteen healthy children (HC), 17 children with CF with normal lung function (CF\u2010N) (FEV<jats:sub>1<\/jats:sub> z\u2010score\u2009\u2265\u2009\u22121.64) and six with airway obstruction (CF\u2010AO) (FEV<jats:sub>1<\/jats:sub> z\u2010score\u2009&lt;\u2009\u22121.64) between 8 and 18 years performed MBNW followed by PExA and spirometry. Children with CF repeated the measurements after 3 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PEx ng\/L and PExNR\/L per liter of exhaled breath were similar between the three groups. The lung clearance index (LCI) was significantly higher in both CF\u2010N and CF\u2010AO compared to HC. All participants, except one, were able to perform PExA. Coefficient of variation for PEx ng\/l was (median) 0.38, range 0\u20131.25 and PExNR\/l 0.38, 0\u20131.09. Correlation between LCI and PEx ng\/l was low, <jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub> 0.32 (<jats:italic>p<\/jats:italic>\u2009=\u2009.07).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PExA is feasible in children. In contrast to LCI, PExA did not differentiate healthy children from children with CF suggesting it to be a less sensitive tool to detect SAD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26847","type":"journal-article","created":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T10:34:49Z","timestamp":1704450889000},"page":"915-922","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of particles in exhaled air and multiple breath washout for assessment of small airway function in children with cystic fibrosis"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4519-9511","authenticated-orcid":false,"given":"Annelies M.","family":"Zwitserloot","sequence":"first","affiliation":[{"name":"University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital Department of Pediatric Pulmonology and Pediatric Allergy Groningen The Netherlands"},{"name":"University of Groningen, University Medical Center Groningen Groningen Research Institute for Asthma and COPD (GRIAC) Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank A.","family":"Verhoog","sequence":"additional","affiliation":[{"name":"University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital Department of Pediatric Pulmonology and Pediatric Allergy Groningen The Netherlands"},{"name":"University of Groningen, University Medical Center Groningen Groningen Research Institute for Asthma and COPD (GRIAC) Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maarten","family":"van den Berge","sequence":"additional","affiliation":[{"name":"University of Groningen, University Medical Center Groningen Groningen Research Institute for Asthma and COPD (GRIAC) Groningen The Netherlands"},{"name":"University of Groningen, University Medical Center Groningen Department of Pulmonary Diseases Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Gappa","sequence":"additional","affiliation":[{"name":"Evangelisches Krankenhaus D\u00fcsseldorf Children's Hospital D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helma W.","family":"Oosterom","sequence":"additional","affiliation":[{"name":"University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital Department of Pediatric Pulmonology and Pediatric Allergy Groningen The Netherlands"},{"name":"University of Groningen, University Medical Center Groningen Groningen Research Institute for Asthma and COPD (GRIAC) Groningen The Netherlands"},{"name":"University of Groningen, University Medical Center Groningen Department of Pulmonary Diseases Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte W. 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