{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:07:11Z","timestamp":1781647631219,"version":"3.54.5"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:00:00Z","timestamp":1705017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The influence of habitual physical activity and exercise capacity on health\u2010related quality of life (HRQoL) in people with cystic fibrosis (pwCF) is poorly characterized. This study investigated the influence of habitual physical activity, exercise capacity, lung function, and body mass index (BMI) on HRQoL in adolescent and adult pwCF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Subjects were fitted with an accelerometer to determine habitual physical activity (steps\/day), including time spent at different intensities, for up to 4 weeks. Then bicycle ergometry (maximal exercise capacity; Wpeak), lung function (percent predicted forced expiratory volume in 1\u2009s, ppFEV<jats:sub>1<\/jats:sub>), BMI, and response to the Cystic Fibrosis Questionnaire\u2010Revised (CFQ\u2010R) were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010five pwCF participated in the study. Physically active pwCF had significantly higher ppFEV<jats:sub>1<\/jats:sub> (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and exercise capacity (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) than inactive pwCF, and had significantly higher scores on the CFQ\u2010R physical (<jats:italic>p<\/jats:italic>\u2009=\u2009.006), emotional (<jats:italic>p<\/jats:italic>\u2009=\u2009.015), role (<jats:italic>p<\/jats:italic>\u2009=\u2009.008), health (<jats:italic>p<\/jats:italic>\u2009=\u2009.006), and weight (<jats:italic>p<\/jats:italic>\u2009=\u2009.004) subscales. On multiple linear regression analysis, ppFEV<jats:sub>1<\/jats:sub> and, to a lesser extent, exercise capacity, were the most important determinants of HRQoL in pwCF. Time spent in moderate\u2010to\u2010vigorous intensity physical activity did not influence any of the CFQ\u2010R subscales, whereas time spent in vigorous\u2010intensity influenced CFQ\u2010R scores for role (<jats:italic>p<\/jats:italic>\u2009=\u2009.007), body (<jats:italic>p<\/jats:italic>\u2009=\u2009.001), health (<jats:italic>p<\/jats:italic>\u2009=\u2009.009), and weight (<jats:italic>p<\/jats:italic>\u2009=\u2009.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HRQoL in adolescent and adult pwCF was influenced by several factors. Avoiding sedentary behavior and spending time in vigorous\u2010intensity levels positively influenced HRQoL, whereas the total number of steps per day played only a minor role in determining HRQoL. Both ppFEV<jats:sub>1<\/jats:sub> and exercise capacity markedly influenced HRQoL.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26855","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T12:16:10Z","timestamp":1705061770000},"page":"949-963","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of habitual physical activity and exercise capacity on quality of life in adolescents and adults with cystic fibrosis"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1259-8911","authenticated-orcid":false,"given":"Matthias","family":"Welsner","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine, University Hospital Essen\u2014Ruhrlandklinik, Adult Cystic Fibrosis Center University of Duisburg\u2010Essen Essen 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