{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T02:48:35Z","timestamp":1771555715585,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:00:00Z","timestamp":1706140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Increase in body mass index (BMI) in early childhood (1\u22126 years) was found to be a contributing factor for impaired final height in boys with Cystic Fibrosis (CF). Early adrenarche (before age 9 years in boys) may contribute to an impaired final height by triggering an early acceleration of bone age resulting in a compromised growth spurt during puberty. We aimed to analyze the timing of adrenarche in boys with CF and to associate BMI increase in early childhood to timing of adrenarche.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Boys with CF, aged 8\u22129 years, visiting the CF expertize center Utrecht were included. Since 2018, anthropomorphic, pubertal and endocrine data were collected. Early adrenarche in boys was defined as a dehydroepiandrosterone sulfate (DHEAS)\u2009\u2265\u20091 \u00b5mol\/L before the age of 9 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen boys (mean age 8.55\u2009\u00b1\u20090.27\u2009years) were enrolled. The median (IQR) DHEAS\u2010level was 1.3 \u00b5mol\/L (0.71\u22122.40). Eight boys (61.5%) had an early rise in DHEAS\u2010levels \u2265 1 \u00b5mol\/L. Mean increase in BMI Z\u2010score between 1 and 6 years of age (\u0394BMI<jats:sub>1\u22126<\/jats:sub>) was \u22120.07\u2009\u00b1\u20090.86. A significant correlation was found between \u0394BMI<jats:sub>1\u22126<\/jats:sub> and DHEAS\u2010levels at the age of 8\u22129 years (<jats:italic>r<\/jats:italic>\u2009=\u20090.624, <jats:italic>p<\/jats:italic>\u2009=\u20090.040). In five boys with early rise in DHEAS, accelerated bone age was found (average 1.55\u2009\u00b1\u20090.96 years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this small cohort, 61.5% of boys with CF between 8 and 9 years had an early rise of DHEAS, which was correlated to \u0394BMI<jats:sub>1<\/jats:sub><jats:sub>\u22126<\/jats:sub> between 1 and 6 years. Early adrenarche may be caused by \u0394BMI<jats:sub>1<\/jats:sub><jats:sub>\u22126<\/jats:sub>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26861","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T11:19:37Z","timestamp":1706181577000},"page":"991-996","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["BMI increase during early childhood in boys with cystic fibrosis and early adrenarche"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9639-3894","authenticated-orcid":false,"given":"Gizem","family":"Tamer","sequence":"first","affiliation":[{"name":"Department of Pediatric Endocrinology, Wilhelmina Children's Hospital University Medical Center Utrecht the Netherlands"},{"name":"Department of Pediatric Pulmonology, Wilhelmina Children's Hospital University Medical Center Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hubertus Gerardus Maria","family":"Arets","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology, Wilhelmina Children's Hospital University Medical Center Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelis Kors","family":"van der Ent","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology, Wilhelmina Children's Hospital University Medical Center Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanneke Margo","family":"van Santen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology, Wilhelmina Children's Hospital University Medical Center Utrecht the Netherlands"},{"name":"Princess M\u00e1xima Center for Pediatric Oncology Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hetty Jacoba","family":"van der Kamp","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology, Wilhelmina Children's Hospital University Medical Center Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.03.004"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2018.02.006"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2014.07.010"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(88)90063-7"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1054\/clnu.1999.0079"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00119714"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24343"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8223(01)00113-4"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.4081\/pr.2012.e35"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnab009"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-10-0119"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.07.043497"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39238.399444.55"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7244.1240"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-2049"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12612"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2006.tb02206.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853890.2010.515603"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031848"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199703000-00023"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2004.17.11.1497"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1998.00514.x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-004-1405-8"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0803691"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.112.037325"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1460537"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.84.11.6093"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2002.126923"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.05.018"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2014.07.012"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.09.059"}],"container-title":["Pediatric 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