{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:16:34Z","timestamp":1790709394873,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cystic fibrosis (CF) is a rare disease in Algeria, and its prognosis is poor in developing countries. The clinical and demographic knowledge of Algerian pediatric patients diagnosed with CF is incomplete due to the nonexistence of a national medical registry. Hence, the present study is the first Algerian multicentre study on CF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study was conducted in western Algeria. Over 1 year, the study included all pediatric patients with a confirmed diagnosis of CF in the pediatric hospital of Oran. Patient characteristics, clinical manifestations, and the prescribed treatment were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010four\u00a0children (16 boys and 18 girls) participated in this study. Only 15 were diagnosed before the age of 6 months. The sweat chloride test was positive in all patients. Respiratory manifestations were found in all patients, chronic diarrhoea in 29 of them, and growth retardation in 10. Moreover, 25 (73.5%) had low to low intermediate socioeconomic levels. After diagnosis, respiratory complications marked the evolution of the 34 patients, with\u00a0bronchial congestion observed\u00a0in 33 of them, while 10 (29.4%) patients presented severe bronchopneumonia and 4 (11.8%) were affected by asthma. Consequently,\u00a0 three (8.8%) died at an average age of 9 years mainly because of respiratory failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prognosis of CF is poor in Algeria compared to other developed countries due to the longer diagnostic delay and limited therapeutic alternatives. This representative subset of Algerian pediatric patients with CF will serve as a reference for future studies on CF in Algeria.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26939","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T12:59:22Z","timestamp":1709038762000},"page":"1454-1461","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Initial characteristics of cystic fibrosis in Algeria: Description of 34 pediatric cases"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6817-4355","authenticated-orcid":false,"given":"Imene","family":"Bendoukha","sequence":"first","affiliation":[{"name":"Laboratory Antibiotics Antifungals: Physico\u2010chemical Synthesis and Biological Activity (LapSab) University of Abou Bekr Belkaid Tlemcen Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahia","family":"Boucherit\u2010Otmani","sequence":"additional","affiliation":[{"name":"Laboratory Antibiotics Antifungals: Physico\u2010chemical Synthesis and Biological Activity (LapSab) University of Abou Bekr Belkaid Tlemcen Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahira Zakia","family":"Baba Ahmed\u2010Kazi Tani","sequence":"additional","affiliation":[{"name":"Laboratory Antibiotics Antifungals: Physico\u2010chemical Synthesis and Biological Activity (LapSab) University of Abou Bekr Belkaid Tlemcen Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelfettah","family":"Seghir","sequence":"additional","affiliation":[{"name":"Laboratory Antibiotics Antifungals: Physico\u2010chemical Synthesis and Biological Activity (LapSab) University of Abou Bekr Belkaid Tlemcen Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mourad","family":"Madouni","sequence":"additional","affiliation":[{"name":"Faculties of Economics and Business and Management University of Tahar Moulay Saida Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdel Karim","family":"Radoui","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pneumology and Allergology Specialised Hospital Establishment of Canastel Oran Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kebir","family":"Boucherit","sequence":"additional","affiliation":[{"name":"Laboratory Antibiotics Antifungals: Physico\u2010chemical Synthesis and Biological Activity (LapSab) University of Abou Bekr Belkaid Tlemcen Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,27]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1191\/1479972306cd111rs"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39391.713229.AD"},{"key":"e_1_2_12_4_1","unstructured":"Cystic Fibrosis Foundation.Patient registry annual data report. 2021.www.cff.org\/medical-professionals\/patient-registry"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-2791"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.10"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2015.10.002"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.7326\/M16-0858"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-020-2013-6"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000000520"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23715"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24523"},{"key":"e_1_2_12_13_1","first-page":"37","article-title":"Cystic fibrosis in low and middle\u2010income countries (LMIC): a view from four different regions of the world","volume":"38","author":"Silva Filho LVRF","year":"2021","journal-title":"Paediatr Respir Rev"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2006.04.083"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2007.04.004"},{"key":"e_1_2_12_16_1","article-title":"Childhood cystic fibrosis: epidemiological approach and clinical study in western Algeria","volume":"295","author":"Radoui A","year":"2012","journal-title":"Facul Med"},{"issue":"5","key":"e_1_2_12_17_1","first-page":"549","article-title":"Detection of CFTR mutations using PCR\/ARMS in a sample of Algerian population","volume":"72","author":"Sediki FZ","year":"2014","journal-title":"ABC"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.48087\/BJMSoa.2021.8107"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcped.2010.06.021"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.respe.2014.11.003"},{"issue":"6","key":"e_1_2_12_21_1","first-page":"435","article-title":"[Consanguinity and public health. 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