{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T08:17:44Z","timestamp":1772612264316,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T00:00:00Z","timestamp":1709596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>It has recently been reported that it is possible to monitor lung oxygenation (rSO<jats:sub>2<\/jats:sub>L) by near\u2010infrared spectroscopy (NIRS) in preterm infants with respiratory distress syndrome (RDS). Thus, our aim was to assess the possibility of monitoring rSO<jats:sub>2<\/jats:sub>L in infants with evolving and established bronchopulmonary dysplasia (BPD) and to evaluate if rSO<jats:sub>2<\/jats:sub>L correlates with BPD severity and other oxygenation indices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied 40 preterm infants with gestational age \u226430 weeks at risk for BPD. Patients were continuously studied for 2\u2009h by NIRS at 28\u2009\u00b1\u20097 days of life and 36 weeks\u2009\u00b1\u20097 days of postmenstrual age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>rSO<jats:sub>2<\/jats:sub>L was similar at the first and second NIRS recordings (71.8\u2009\u00b1\u20097.2 vs. 71.4\u2009\u00b1\u20094.2%) in the overall population, but it was higher in infants with mild than in those with moderate\u2010to\u2010severe BPD at both the first (73.3\u2009\u00b1\u20093.1 vs. 71.2\u2009\u00b1\u20093.2%, <jats:italic>p<\/jats:italic>\u2009=\u2009.042) and second (72.3\u2009\u00b1\u20092.8 vs. 70.5\u2009\u00b1\u20092.8, <jats:italic>p<\/jats:italic>\u2009=\u2009.049) NIRS recording. A rSO<jats:sub>2<\/jats:sub>L cutoff value of 71.6% in the first recording was associated with a risk for moderate\u2010to\u2010severe BPD with a sensitivity of 66% and a specificity of 60%. Linear regression analysis demonstrated a significant positive relationship between rSO<jats:sub>2<\/jats:sub>L and SpO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub> ratio (<jats:italic>p<\/jats:italic>\u2009=\u2009.013) and a\/APO<jats:sub>2<\/jats:sub> (<jats:italic>p<\/jats:italic>\u2009=\u2009.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Monitoring of rSO<jats:sub>2<\/jats:sub>L by NIRS in preterm infants with evolving and established BPD is feasible and safe. rSO<jats:sub>2<\/jats:sub>L was found to be higher in infants with mild BPD, and predicts the risk for developing moderate\u2010to\u2010severe BPD and correlates with other indices of oxygenation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26955","type":"journal-article","created":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T14:08:35Z","timestamp":1709647715000},"page":"1631-1637","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Measurement of lung oxygenation by near\u2010infrared spectroscopy in preterm infants with bronchopulmonary dysplasia"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1639-621X","authenticated-orcid":false,"given":"Carlo","family":"Dani","sequence":"first","affiliation":[{"name":"Division of Neonatology Careggi University Hospital of Florence Florence Italy"},{"name":"Department of Neurosciences, Psychology, Drug Research and Child Health Careggi University Hospital of Florence Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Miselli","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Department of Medical and Surgical Sciences of Mothers,\u00a0Children and Adults University Hospital of Modena Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tommaso","family":"Zini","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Department of Medical and Surgical Sciences of Mothers,\u00a0Children and Adults University Hospital of Modena Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Scarponi","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Department of Medical and Surgical Sciences of Mothers,\u00a0Children and Adults University Hospital of Modena Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Luzzati","sequence":"additional","affiliation":[{"name":"Division of Neonatology Careggi University Hospital of Florence Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Sarcina","sequence":"additional","affiliation":[{"name":"Division of Neonatology Careggi University Hospital of Florence Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Fusco","sequence":"additional","affiliation":[{"name":"Division of Neonatology Careggi University Hospital of Florence Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Dianori","sequence":"additional","affiliation":[{"name":"Division of Neonatology Careggi University Hospital of Florence Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3534-7499","authenticated-orcid":false,"given":"Alberto","family":"Berardi","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Department of Medical and Surgical Sciences of Mothers,\u00a0Children and Adults University Hospital of Modena Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-2959"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0127-7"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.10244"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.104.2.e17"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1605566"},{"key":"e_1_2_9_7_1","unstructured":"NetworkVO. 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