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The extent of remaining healthy pancreatic parenchyma determines the risk of developing future episodes of pancreatitis, as well as pancreatic exocrine or endocrine insufficiency. Pancreatitis may be the presenting symptom of CF, and genetic testing is especially important in pediatrics. AP and recurrent AP are managed with intravenous fluid hydration and pain control, in addition to early refeeding and treatment of complications. With the use of modulator therapy in CF, pancreatic function may be restored to some extent. CP related pain is managed with analgesics and neuromodulators, with surgery if indicated in specific situations including TPIAT as a possible type of surgical intervention. Long\u2010term sequelae of CP in patients with CF include exocrine pancreatic insufficiency treated with pancreatic enzyme replacement therapy, fat\u2010soluble vitamin deficiencies and associated metabolic complications such as bone disease\/osteoporosis, pancreatogenic diabetes, and less commonly, pancreatic cancer. We review the presentation and etiologies of pancreatitis in CF patients as well as the management of AP and CP primarily in children.<\/jats:p>","DOI":"10.1002\/ppul.26958","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T10:05:59Z","timestamp":1710842759000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pancreatitis in cystic fibrosis: Presentation, medical and surgical management, and the impact of modulator therapies"],"prefix":"10.1002","volume":"59","author":[{"given":"Reza V.","family":"Milano","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Digestive Health and Liver Diseases University of Miami, Leonard M. Miller School of Medicine Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayla","family":"Morneault\u2010Gill","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Gastroenterology University of Florida, College of Medicine Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hebat Y.","family":"Kamal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Gastroenterology University of Florida, College of Medicine Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7753-0638","authenticated-orcid":false,"given":"Jodie A.","family":"Barkin","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Digestive Health and Liver Diseases University of Miami, Leonard M. 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