{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T11:31:15Z","timestamp":1762342275804,"version":"3.37.3"},"reference-count":53,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>An ultrasound\u2010based diagnosis implies that some fetuses suspected to be growth\u2010restricted (FGR) are discovered at birth to be appropriately grown (appropriate for gestational age [AGA] birth weight, between the 10th and 90th percentile). These fetuses may thus be exposed to unnecessary medical interventions, including early labor induction. In this study, we have evaluated the long\u2010term respiratory health of offspring misclassified as FGR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>A population\u2010based cohort analysis was conducted, including deliveries of AGA singletons between 1991 and 2021 at a tertiary referral hospital. Incidence of morbidity due to various respiratory conditions was compared between AGA offspring with prenatal diagnosis of FGR, and those without a false diagnosis of FGR. The Kaplan\u2013Meier approach was used to estimate cumulative morbidity incidence. The stratified Cox proportional\u2010hazards model was used to control for confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 324,620 deliveries of AGA newborns were included in the analyses; 3249 of them (1.0%) were misclassified prenatally as FGR. The FGR subgroup delivered at an earlier gestational age (36.7 vs. 39.1 weeks, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and had more than 25% higher incidence of respiratory\u2010related morbidity during childhood (33.2% vs. 26.5%), specifically related to asthma and obstructive sleep apnea (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001 for all). A higher cumulative morbidity rate due to respiratory conditions was observed in the Kaplan\u2013Meier survival curve (log\u2010rank <jats:italic>p<\/jats:italic> value\u2009&lt;\u2009.001). This association between FGR and respiratory morbidity was independent of preterm delivery, maternal age, cesarean delivery, and child's birth year (adjusted hazard ratio\u2009=\u20091.14, 95% confidence interval: 1.07\u20131.21, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), using a Cox proportional hazards model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>AGA newborns misclassified as FGR, are at an increased risk for long\u2010term respiratory morbidity during childhood and adolescence.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.26964","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T13:31:54Z","timestamp":1710336714000},"page":"1645-1651","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Respiratory morbidity among offspring misclassified as growth 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