{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:25:02Z","timestamp":1787243102851,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"Abstract<\/jats:title>\n \n Objectives<\/jats:title>\n \n In adults, an isolated low FEV\n 1<\/jats:sub>\n pattern (an FEV\n 1<\/jats:sub>\n below the lower limit of normal with a preserved FVC and FEV\n 1<\/jats:sub>\n \/FVC) has been associated with the risk of developing airway obstruction. Our objective was to examine the prevalence, stability, and clinical significance of an isolated low FEV\n 1<\/jats:sub>\n pattern in the pediatric population.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We conducted a retrospective study of spirometries from children ages 6\u221221 years and categorized tests into spirometry patterns according to published guidelines and recent literature. In a subgroup of tests with an isolated low FEV\n 1<\/jats:sub>\n pattern, we evaluated spirometry technique. We also examined the association of having a test with an isolated low FEV\n 1<\/jats:sub>\n pattern with clinical markers of disease severity in a subgroup of children with cystic fibrosis (CF).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The isolated low FEV\n 1<\/jats:sub>\n pattern was uncommon across the 29,979 tests included (\n n<\/jats:italic>\n \u2009=\u2009645 [2%]). In the 263 children with an isolated low FEV\n 1<\/jats:sub>\n pattern who had a follow\u2010up test performed, the most frequent spirometry pattern at last test was normal (\n n<\/jats:italic>\n \u2009=\u2009123 [47%]). A primary diagnosis of CF was associated with increased odds of having at least one test with an isolated low FEV\n 1<\/jats:sub>\n pattern (OR\u2009=\u20098.37, 95%\u00a0CI\u2009=\u20094.70\u221215.96,\n p<\/jats:italic>\n \u2009<\u2009.001). The spirometry quality in a subgroup of tests with an isolated low FEV\n 1<\/jats:sub>\n pattern (\n n<\/jats:italic>\n \u2009=\u200950) was satisfactory. In the subgroup of children with CF (\n n<\/jats:italic>\n \u2009=\u2009102), those who had a test with an isolated low FEV\n 1<\/jats:sub>\n pattern had higher odds of using oral antibiotics in the last 12 months than those who had a normal pattern (OR\u2009=\u20093.50, 95%\u00a0CI\u2009=\u20091.15\u221210.63,\n p<\/jats:italic>\n \u2009=\u2009.03).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The isolated low FEV\n 1<\/jats:sub>\n pattern can occur repeatedly over time, usually transitions to a normal pattern, is not due to a poor spirometry technique, and could be clinically relevant in children with chronic lung diseases.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ppul.26987","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T09:34:56Z","timestamp":1711964096000},"page":"1747-1756","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prevalence, stability, and clinical significance of an isolated low FEV\n 1<\/sub>\n spirometry pattern in children"],"prefix":"10.1002","volume":"59","author":[{"given":"MacKenzie L.","family":"Wyatt","sequence":"first","affiliation":[{"name":"Department of Pediatrics Vanderbilt University Medical Center Nashville Tennessee USA"},{"name":"Department of Pediatrics University of Washington Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew G.","family":"Sokolow","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebekah F.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1832-9096","authenticated-orcid":false,"given":"Jacob A.","family":"Kaslow","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James J.","family":"Tolle","sequence":"additional","affiliation":[{"name":"Department of Medicine Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Weiner","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6644-5780","authenticated-orcid":false,"given":"Christian","family":"Rosas\u2010Salazar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01499-2021"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00035205"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.10.0720"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-29922-0"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-0804"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.178.4.431a"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201908-1590ST"},{"key":"e_1_2_11_9_1","unstructured":"Beeckman\u2010WagnerL\u2010AF FreelandD. Spirometry quality assurance; common errors and their impact on test results."},{"key":"e_1_2_11_10_1","first-page":"1","article-title":"CDC growth charts: United States","volume":"314","author":"Kuczmarski RJ","year":"2000","journal-title":"Adv Data"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00080312"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202205-0963OC"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00054014"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201605-1039OC"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.2466\/pr0.1966.19.1.3"},{"key":"e_1_2_11_16_1","volume-title":"R: A language and environment for statistical computing","author":"R Development Core Team","year":"2006"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1109\/MPUL.2013.2289511"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(21)00369-6"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00193-2023"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-14-148"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-1235"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1513737"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6077.1645"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(18)30099-7"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(18)30100-0"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(22)00364-2"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2004.12.002"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200111-056OC"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.26987","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T09:33:43Z","timestamp":1737106423000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.26987"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/ppul.26987"],"URL":"https:\/\/doi.org\/10.1002\/ppul.26987","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"2023-12-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}