{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:13:44Z","timestamp":1791357224893,"version":"4.3.1"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:00:00Z","timestamp":1712102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>To compare the effects of neurally adjusted ventilatory assist (NAVA) with other forms of synchronized artificial ventilation in preterm infants.\u00a0A systematic review of randomized and quasi\u2010randomized controlled trials\u00a0with individual group allocation, both parallel\u2010group trials as well as crossover trials, that included preterm infants born at less than 37 weeks gestational age and compared NAVA with any other form of synchronized mechanical ventilation with or without volume guarantee. Primary outcomes were death or bronchopulmonary dysplasia (BPD) at 36 weeks, total duration of respiratory support and neurodevelopmental outcome at 2 years. Secondary outcomes consisted of important procedural and clinical outcomes.\u00a0Seven studies with a total of 191 infants were included, five randomized crossover trials and two parallel group randomized trials. No significant difference in the primary outcome of death or BPD (RR: 1.08, 95% CI:\u00a00.33\u22123.55) was found. Peak inspiratory pressures were significantly lower with NAVA than with other forms of ventilation (MD \u22121.83\u2009cmH<jats:sub>2<\/jats:sub>O [95% CI: \u22122.95 to \u22120.71]). No difference in any other clinical or ventilatory outcome was detected.\u00a0Although associated with lower peak inspiratory pressures, the use of NAVA\u00a0does not result in a reduced risk of death or BPD as compared to other forms of synchronized ventilation in preterm infants. However, the certainty of evidence is low due to imprecision of the effect estimate. Larger studies are needed to detect possible short\u2010 and long\u2010term differences between ventilation modes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.27001","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T13:55:03Z","timestamp":1712152503000},"page":"1862-1870","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Neurally adjusted ventilatory assist in preterm infants: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1881-7388","authenticated-orcid":false,"given":"Julie","family":"Lefevere","sequence":"first","affiliation":[{"name":"Department of Neonatology UZ Brussel Jette Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda","family":"van Delft","sequence":"additional","affiliation":[{"name":"Department of Neonatology UZ Brussel Jette Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim","family":"Decaluwe","sequence":"additional","affiliation":[{"name":"Department of Neonatology AZ Sint\u2010Jan Brugge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Derriks","sequence":"additional","affiliation":[{"name":"Department of Neonatology UZ Brussel Jette Belgium"},{"name":"Department of Neonatology, Clinique universitaires de Bruxelles H\u00f4pital Erasme Bruxelles Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip","family":"Cools","sequence":"additional","affiliation":[{"name":"Department of Neonatology UZ Brussel Jette Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,3]]},"reference":[{"issue":"8","key":"e_1_2_10_2_1","first-page":"874","article-title":"Neurally adjusted ventilatory assist (NAVA) in children: a systematic review","volume":"82","author":"Beck J","year":"2016","journal-title":"Minerva Anestesiol"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.10.014"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000367886"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-020-03728-y"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e31819e72ab"},{"key":"e_1_2_10_7_1","first-page":"10","article-title":"Neurally adjusted ventilatory assist compared to other forms of triggered ventilation for neonatal respiratory support","volume":"2017","author":"Rossor TE","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_8_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions version 6.4 (updated August 2023)","author":"Cumpston M","year":"2023"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n160"},{"key":"e_1_2_10_10_1","unstructured":"SterneJAC Savovi\u0107J PageMJ et al. Revised Cochrane risk\u2010of\u2010bias tool for randomized trials (Rob 2). 2019.https:\/\/www.riskofbias.info\/"},{"key":"e_1_2_10_11_1","unstructured":"HigginsJPT LiT Sterne J on behalf of the RoB2 Working Group on Crossover Trials. Revised Cochrane risk\u2010of\u2010bias tool for randomized trials (Rob 2). Additional considerations for crossover trials. 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