{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T01:05:43Z","timestamp":1785287143561,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:00:00Z","timestamp":1714608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Rationale<\/jats:title><jats:p>Lung T1 MRI is a potential method to assess cystic fibrosis (CF)\u00a0lung disease that is safe, quick, and widely available, but there are no data in children with mild CF lung disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Assess the ability of lung T1 MRI to detect abnormalities in children with mild CF lung disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed T1 MRI, multiple breath washout (MBW),\u00a0chest computed tomography (CT),\u00a0and spirometry in a cohort of 45 children with mild CF lung disease (6\u201311 years of age).<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Results<\/jats:title><jats:p>Despite mean normal ppFEV1 values, the majority of children with CF in this study exhibited mild lung disease evident in lung clearance index (LCI)\u00a0measured by MBW, chest CT Brody scores, and percent normal lung perfusion (%NLP)\u00a0measured by T1 MRI. The %NLP correlated with chest CT Brody scores, as did LCI, but %NLP and LCI did not correlate with each other. Analysis of the Brody subscores showed that %NLP and LCI largely correlated with different Brody subscores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>T1 MRI can detect mild CF lung disease in children and correlates with chest CT findings. The %NLP\u00a0from T1 MRI and LCI correlate with different chest CT Brody subscores, suggesting they provide complementary information about CF lung disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.27039","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T12:59:44Z","timestamp":1714654784000},"page":"2464-2471","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Lung T1 MRI assessments in children with mild cystic fibrosis lung disease"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4431-0644","authenticated-orcid":false,"given":"Clement L.","family":"Ren","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Sleep Medicine Children's Hospital of Philadelphia Philadelphia Pennsylvania USA"},{"name":"Department of Pediatrics, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samya Z.","family":"Nasr","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Michigan Medicine University of Michigan Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Slaven","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Indiana University School of Medicine Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aparna","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Michigan Medicine University of Michigan Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam Ghadimi","family":"Mahani","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Michigan Medicine University of Michigan Ann Arbor Michigan USA"},{"name":"Advanced Radiology Services Lansing Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Clem","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy, and Sleep Medicine Riley Hospital for Children Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Cooper","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy, and Sleep Medicine Riley Hospital for Children Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Farr","sequence":"additional","affiliation":[{"name":"Imaging Research Core Case Western Reserve University Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina J.","family":"MacAskill","sequence":"additional","affiliation":[{"name":"Imaging Research Core Case Western Reserve University Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise","family":"Keshock","sequence":"additional","affiliation":[{"name":"Imaging Research Core Case Western Reserve University Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Nicholas","sequence":"additional","affiliation":[{"name":"Department of Radiology, Rainbow Babies and Children's Hospital University Hospitals \u2010 Cleveland Medical Center Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Ferrebee","sequence":"additional","affiliation":[{"name":"Department of Radiology, Rainbow Babies and Children's Hospital University Hospitals \u2010 Cleveland Medical Center Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9642-3814","authenticated-orcid":false,"given":"Kimberly","family":"McBennett","sequence":"additional","affiliation":[{"name":"Imaging Research Core Case Western Reserve University Cleveland Ohio USA"},{"name":"Department of Radiology, Rainbow Babies and Children's Hospital University Hospitals \u2010 Cleveland Medical Center Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris A.","family":"Flask","sequence":"additional","affiliation":[{"name":"Imaging Research Core Case Western Reserve University Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60327-5"},{"key":"e_1_2_9_3_1","unstructured":"Cystic Fibrosis Foundation Patient Registry 2021 Annual Data Report;2022."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.06697"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202207-1356ED"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000225373"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2007.077784"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2010.06.010"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00069712"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(19)30187-0"},{"issue":"1","key":"e_1_2_9_11_1","first-page":"S40","article-title":"Novel imaging techniques for cystic fibrosis lung disease","volume":"56","author":"Goralski JL","year":"2021","journal-title":"Pediatr Pulmonol"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.10134"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2018.04.024"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201603-203OC"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2020.11.019"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201604-0893OC"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2016.12.008"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2015.11.009"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21446"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.27746"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20051"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.27271"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20110"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073286"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.28907"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201908-1590ST"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21188"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201105-0816OC"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24144"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.rti.0000203937.82276.ce"},{"key":"e_1_2_9_31_1","unstructured":"National Newborn Screening Report 2000;2003."},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01302-2019"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.150375"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201507-1409OC"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02398-2021"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201501-0061OC"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.27039","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,17]],"date-time":"2024-11-17T12:12:09Z","timestamp":1731845529000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.27039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,2]]},"references-count":35,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1002\/ppul.27039"],"URL":"https:\/\/doi.org\/10.1002\/ppul.27039","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,2]]},"assertion":[{"value":"2023-06-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}