{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T09:07:23Z","timestamp":1777712843693,"version":"3.51.4"},"reference-count":65,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:00:00Z","timestamp":1714608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Despite medical advancement, pediatric pulmonary tuberculosis (PTB) still has high morbidity and mortality, due to challenging detection in clinical practice. Ultrasound has been touted as the next best diagnostic tool but currently, this claim is unfounded. Therefore, this study aims to systematically review the diagnostic parameters of chest ultrasound in diagnosing pediatric PTB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The literature search started and ended on December 23, 2023. We searched MEDLINE, Cochrane Library, Pubmed, Science Direct, and Google Scholar. Our research question could be formulated as \u201cIn pediatric patients who present with signs and symptoms of PTB such as fever, cough, and poor weight gain, how accurate is chest ultrasound in ruling in and ruling out pediatric PTB when the diagnosis is compared to culture, PCR or CXR?\u201d This systematic review adhered to the PRISMA\u2010DTA guidelines while the meta\u2010analysis was conducted with STATA program using the \u201cmidas\u201d and \u201cmetandi\u201d commands.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There are five studies included with 137 positive PTB children. The combined sensitivity is 84% (95% confidence interval [CI]: 76\u201389), specificity of 38% (95% CI: 24\u201354), and summary receiver operating curve yields an area under the curve of 0.83 (95% CI: 0.80\u20130.86). The <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> value is 24% (95% CI: 0\u2013100) with a <jats:italic>p<\/jats:italic>\u2010value of 0.13. The combined negative predictive value is 0.68 (95% CI: 0.58\u20130.79), and the positive predictive value is 0.57 (95% CI: 0.51\u20130.63). The positive likelihood ratio is 1 with a 6% increase from the baseline while the negative likelihood ratio is 0.43 with a 12% decrease from the baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Chest ultrasound is sensitive but currently could neither exclude nor confirm pediatric PTB.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.27044","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T12:59:44Z","timestamp":1714654784000},"page":"2381-2391","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A systematic review and meta\u2010analysis of diagnostic test accuracy of chest ultrasound in diagnosing pediatric pulmonary tuberculosis"],"prefix":"10.1002","volume":"59","author":[{"given":"Rusli","family":"Muljadi","sequence":"first","affiliation":[{"name":"Department of Radiology, Thoracic and Cardiovascular Imaging Division Faculty of Universitas Pelita Harapan Tangerang Indonesia"},{"name":"Department of Radiology of Siloam Hospital Lippo Village Tangerang Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Koesbandono","sequence":"additional","affiliation":[{"name":"Department of Radiology of Siloam Hospital Lippo Village Tangerang Indonesia"},{"name":"Interventional Radiology Division, Department of Radiology Faculty of Universitas Pelita Harapan Tangerang Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6439-6265","authenticated-orcid":false,"given":"Gilbert S.","family":"Octavius","sequence":"additional","affiliation":[{"name":"Radiology Resident Faculty of Universitas Pelita Harapan Tangerang Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,2]]},"reference":[{"issue":"1","key":"e_1_2_9_2_1","first-page":"E9","article-title":"The history of tuberculosis: from the first historical records to the isolation of Koch's bacillus","volume":"58","author":"Barberis I","year":"2017","journal-title":"J Prev Med Hyg"},{"key":"e_1_2_9_3_1","unstructured":"World Health Organization.Tuberculosis. 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