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This shift in life expectancy demands increased attention to diseases of aging in patients with CF. A notable complication of CF is early\u2010onset colorectal cancer (CRC), which is especially prevalent in patients with severe mutations and after transplant. <jats:italic>CFTR<\/jats:italic> acts as a tumor suppressor gene based on knockout models. Lack of CFTR expression promotes carcinogenic processes such as intestinal inflammation and deleterious gut microbiome changes. The consensus Cystic Fibrosis Foundation recommendations advocate treating this population as a high\u2010risk group, using a colonoscopy\u2010only screening strategy starting at age 40 in patients without transplant and at age 30 after transplant. Screening should be considered every 5 years if negative and every 3 years or sooner for patients with adenomatous polyps. Future research will determine the role of noninvasive CRC screening tools in this population, as well as the effects of CFTR modulators on the risk of developing CRC.<\/jats:p>","DOI":"10.1002\/ppul.27060","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T09:34:59Z","timestamp":1722936899000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evolving data on risk and current screening recommendations for colorectal cancer in cystic fibrosis: Pre\u2010 and posttransplant"],"prefix":"10.1002","volume":"59","author":[{"given":"Zain","family":"Raza","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology &amp; Hepatology Saint Louis University School of Medicine Saint Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca N.","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology and Liver Disease University Hospitals Cleveland Medical Center Cleveland Ohio USA"},{"name":"Department of Medicine Case Western Reserve University, School of Medicine Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine Y.","family":"Hachem","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology &amp; Hepatology Saint Louis University School of Medicine Saint Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8767-2795","authenticated-orcid":false,"given":"Linda C.","family":"Cummings","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology and Liver Disease University Hospitals Cleveland Medical Center Cleveland Ohio USA"},{"name":"Department of Medicine Case Western Reserve University, School of Medicine Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200505-840OE"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.7326\/M13-0636"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2017.11.019"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01444-2015"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2017-210394"},{"key":"e_1_2_10_7_1","unstructured":"Cystic Fibrosis Foundation. 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