{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:45:23Z","timestamp":1792291523099,"version":"4.4.0"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:00:00Z","timestamp":1718064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Cystic fibrosis transmembrane conductance regulator (CFTR) modulator elexacaftor\/tezacaftor\/ivacaftor (ETI) significantly improves lung function but its effect on mental health and sleep remains poorly understood. We report on mental health, sleep, and respiratory health outcomes of adolescents with CF commenced on ETI therapy, and monitored the prevalence of neuropsychiatric issues through the\u00a0coronavirus disease 2019 pandemic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a prospective longitudinal study of 31 adolescents (aged 10\u201318 years) from July 2021 to October 2022. Data collected include demographics, Patient Health Questionnaire\u20109 (PHQ\u20109), General Anxiety Disorder\u20107 (GAD\u20107), Pediatric Daytime Sleepiness Scale (PDSS), Sleep Disturbance Scale for Children (SDSC) scores, and FEV\n                      <jats:sub>1<\/jats:sub>\n                      percent predicted. Twenty of 31 adolescents had data before and after ETI initiation. Mean differences (MD) in mental health, sleep, and respiratory health pre\u2010 and post\u2010ETI therapy commencement were estimated using paired\n                      <jats:italic>t<\/jats:italic>\n                      \u2010tests. The prevalence and trajectories of anxiety, depression, and sleep disturbance were described between the ETI epochs, and over the pandemic period.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      FEV\n                      <jats:sub>1<\/jats:sub>\n                      improved following ETI therapy commencement (MD, 95% confidence interval [CI]: 7.1% (4.7%\u20139.6%) whereas PHQ\u20109, GAD\u20107, PDSS, and SDSC scores did not change significantly. Ten percent of participants developed new\u2010onset anxiety\/depression concerns and 10% developed new sleep concerns following ETI initiation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This is the first prospective longitudinal study of mental health and sleep changes after ETI commencement in adolescents with CF. Although respiratory outcomes improved, ETI did not improve anxiety, depression or sleep.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.27100","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T13:23:34Z","timestamp":1718112214000},"page":"2606-2613","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Mental health, sleep, and respiratory health after initiating elexacaftor\/tezacaftor\/ivacaftor treatment in children with cystic fibrosis"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5435-6526","authenticated-orcid":false,"given":"Hiep","family":"Pham","sequence":"first","affiliation":[{"name":"Respiratory and Sleep Medicine, The Royal Children's Hospital Parkville Victoria Australia"},{"name":"Respiratory Diseases, Murdoch Research Children's Institute, Royal Children's Hospital Parkville Victoria 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