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Validation of the <jats:italic>IPOS<\/jats:italic> is needed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This secondary analysis utilized baseline data from a multisite trial of the palliative care model, <jats:italic>Improving Life with CF<\/jats:italic>. Adults with CF completed the <jats:italic>IPOS<\/jats:italic>, the <jats:italic>Memorial Symptom Assessment Scale\u2010CF (MSAS\u2010CF)<\/jats:italic>, the <jats:italic>CF Questionnaire\u2010Revised (CFQ\u2010R)<\/jats:italic>, the <jats:italic>Patient Health Questionnaire (PHQ\u20108)<\/jats:italic>, the <jats:italic>Generalized Anxiety Disorder (GAD\u20107)<\/jats:italic>, and the <jats:italic>Perceived Stress Scale (PSS). IPOS<\/jats:italic> structure was assessed using Cronbach <jats:italic>\u03b1<\/jats:italic> coefficients and a factor analysis. Construct validity was evaluated through bivariate relationships between <jats:italic>IPOS<\/jats:italic> scores and other questionnaire scores, and linear regressions assessing the extent to which the <jats:italic>IPOS<\/jats:italic> explains variance in quality\u2010of\u2010life domains.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The sample comprised 256 adults with complete <jats:italic>IPOS<\/jats:italic> data. <jats:italic>\u03b1<\/jats:italic> coefficients were .86 for the <jats:italic>IPOS<\/jats:italic> total score, .81 for the Physical Symptoms subscale, .79 for the Emotional Symptoms subscale, and .63 for the Communication\/Practical Issues subscale. A two\u2010component factor structure best aligned with the current subscales. <jats:italic>IPOS<\/jats:italic> scores were significantly associated with other measures; associations with <jats:italic>MSAS\u2010CF<\/jats:italic> and <jats:italic>CFQ\u2010R<\/jats:italic> subscales differentiated the <jats:italic>IPOS<\/jats:italic> Physical and Emotional subscales. The <jats:italic>IPOS<\/jats:italic> total score provided unique information about the variance in the <jats:italic>CFQ\u2010R<\/jats:italic> Physical Functioning and Respiratory Symptoms domain scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In adults with CF, the <jats:italic>IPOS<\/jats:italic> has acceptable internal consistency and there is evidence of construct validity. These findings support adoption of the <jats:italic>IPOS<\/jats:italic> in the primary palliative care model for CF.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.27143","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T14:52:57Z","timestamp":1719499977000},"page":"2857-2866","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Validation of the Integrated Palliative Care Outcome Scale (<i>IPOS<\/i>) in adults with cystic fibrosis"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0924-4031","authenticated-orcid":false,"given":"Anna M.","family":"Georgiopoulos","sequence":"first","affiliation":[{"name":"Department of Psychiatry Massachusetts General Hospital Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"DiFiglia","sequence":"additional","affiliation":[{"name":"MJHS Institute for 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