{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T13:21:15Z","timestamp":1770729675519,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T00:00:00Z","timestamp":1719964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Preterm infants close to viability commonly require mechanical ventilation (MV) for respiratory distress syndrome. Despite commonly used lung\u2010sparing ventilation techniques, rapid lung expansion during MV induces lung injury, a risk factor for bronchopulmonary dysplasia. This study investigates whether ventilation with optimized lung expansion is feasible and whether it can further minimize lung injury. Therefore, optimized lung expansion ventilation (OLEV) was compared to conventional volume targeted ventilation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty preterm lambs were surgically delivered after 132 days of gestation. Nine animals were randomized to receive OLEV for 24\u2009h, and seven received standard MV. Four unventilated animals served as controls (NV). Lungs were sampled for histological analysis at the end of the experimental period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ventilation with OLEV was feasible, resulting in a significantly higher mean ventilation pressure (0.7\u20131.3\u2009mbar). Temporary differences in oxygenation between OLEV and MV did not reach clinically relevant levels. Ventilation in general tended to result in higher lung injury scores compared to NV, without differences between OLEV and MV. While pro\u2010inflammatory tumor necrosis factor\u2010\u03b1 messenger RNA (mRNA) levels increased in both ventilation groups compared to NV, only animals in the MV group showed a higher number of CD45\u2010positive cells in the lung. In contrast, mean (standard deviations) surfactant protein\u2010B mRNA levels were significantly lower in OLEV, 0.63 (0.38) compared to NV 1.03 (0.32) (<jats:italic>p<\/jats:italic>\u2009=\u2009.023, one\u2010way analysis of variance).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In conclusion, a small reduction in pulmonary inflammation after 24\u2009h of support with OLEV suggests potential to reduce preterm lung injury.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.27153","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T11:55:03Z","timestamp":1720007703000},"page":"2891-2900","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Optimized lung expansion ventilation modulates ventilation\u2010induced lung injury in preterm lambs"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4010-5356","authenticated-orcid":false,"given":"Tim","family":"Brokken","sequence":"first","affiliation":[{"name":"Divisions of Neonatology MosaKids Children's Hospital, Maastricht University Medical Center Maastricht The Netherlands"},{"name":"GROW School for Oncology and Reproduction, Faculty of Health, Medicine and Life Sciences, Maastricht University Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias C.","family":"H\u00fctten","sequence":"additional","affiliation":[{"name":"Divisions of Neonatology MosaKids Children's Hospital, Maastricht University Medical Center Maastricht The Netherlands"},{"name":"GROW School for Oncology and Reproduction, Faculty of Health, Medicine and Life Sciences, Maastricht University Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daan R. M. G.","family":"Ophelders","sequence":"additional","affiliation":[{"name":"Divisions of Neonatology MosaKids Children's Hospital, Maastricht University Medical Center Maastricht The Netherlands"},{"name":"GROW School for Oncology and Reproduction, Faculty of Health, Medicine and Life Sciences, Maastricht University Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"van Gorp","sequence":"additional","affiliation":[{"name":"Divisions of Neonatology MosaKids Children's Hospital, Maastricht University Medical Center Maastricht The Netherlands"},{"name":"GROW School for Oncology and Reproduction, Faculty of Health, Medicine and Life Sciences, Maastricht University Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim G. A. M.","family":"Wolfs","sequence":"additional","affiliation":[{"name":"Divisions of Neonatology MosaKids Children's Hospital, Maastricht University Medical Center Maastricht The Netherlands"},{"name":"GROW School for Oncology and Reproduction, Faculty of Health, Medicine and Life Sciences, Maastricht University Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Wald","sequence":"additional","affiliation":[{"name":"Divisions of Neonatology, Department of Pediatrics and Adolescent Medicine Paracelsus Medical University Salzburg Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9051539"},{"issue":"5","key":"e_1_2_9_3_1","first-page":"448","article-title":"Patterns and etiology of acute and chronic lung injury: insights from experimental evidence","volume":"16","author":"H\u00fctten MC","year":"2014","journal-title":"Zhongguo Dang Dai Er Ke Za Zhi"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-2959"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2011.98"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2019.0516"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","unstructured":"ReisMD GommersD LachmannB.Open lung management.Mechanical Ventilation: Clinical Applications and Pathophysiology.2008:276\u2010285.","DOI":"10.1016\/B978-0-7216-0186-1.50029-6"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199904000-00035"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/siny.2002.0129"},{"key":"e_1_2_9_10_1","unstructured":"Medical Science Monitor | High peak inspiratory flow can aggravate ventilator\u2010induced lung injury in rabbits \u2010 Article abstract #480297. 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