{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:27:04Z","timestamp":1791289624590,"version":"4.3.0"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T00:00:00Z","timestamp":1719878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>An inadequate clearance of lung fluid plays a key role in the pathogenesis of transient tachypnea of the newborn (TTN).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate if left ventricular diastolic dysfunction contributes to reduced clearance of lung fluid in TTN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This was a prospective, observational study. Echocardiography and lung ultrasound were performed at 2, 24 and 48\u2009h of life (HoL) to assess biventricular function and calculate lung ultrasound score (LUS). Left atrial strain reservoir (LASr) provided surrogate measurement of left ventricular diastolic function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010seven neonates with TTN were compared with 27 controls with no difference in gestation (36.1\u2009\u00b1\u20092 vs. 36.9\u2009\u00b1\u20092 weeks) or birthweight (2508\u2009\u00b1\u2009667 vs. 2718\u2009\u00b1\u2009590\u2009g). Biventricular systolic function was normal in both groups. LASr was significantly lower in cases at 2 (21.0\u2009\u00b1\u20092.7 vs. 38.1\u2009\u00b1\u20094.4; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), 24 (25.2\u2009\u00b1\u20094.5 vs. 40.6\u2009\u00b1\u20094.0; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and 48 HoL (36.5\u2009\u00b1\u20095.8 and 41.6\u2009\u00b1\u20095.2; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), resulting in a significant group by time interaction (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), after adjusting for LUS and gestational diabetes. A logistic regression model including LUS, birth weight and gestational diabetes as covariates, showed that LASr at 2 HoL was a predictor of respiratory support at 24 HoL, with an adjusted odds ratio of 0.60 (CI 0.36\u20130.99).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>LASr was reduced in neonates with TTN, suggesting diastolic dysfunction, that may contribute to the delay in lung fluid clearance.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.27156","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T13:24:46Z","timestamp":1719926686000},"page":"2910-2921","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Left atrial strain assessment unveils left ventricular diastolic dysfunction in neonates with transient tachypnea of the newborn: A prospective observational study"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6056-5757","authenticated-orcid":false,"given":"Benjamim","family":"Ficial","sequence":"first","affiliation":[{"name":"Neonatal Intensive Care Unit Azienda Ospedaliera Universitaria Integrata Verona Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Dolce","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Science University of Naples Federico II Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4628-3364","authenticated-orcid":false,"given":"Enrico","family":"Petoello","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit Azienda Ospedaliera Universitaria Integrata Verona Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4160-0125","authenticated-orcid":false,"given":"Alice 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Sciences Universit\u00e0 \u201cFederico II\u201d di Napoli Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco Maria","family":"Risso","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Children's Hospital ASST Spedali Civili di Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renzo","family":"Beghini","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit Azienda Ospedaliera Universitaria Integrata Verona Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Dani","sequence":"additional","affiliation":[{"name":"Division of Neonatology Careggi University Hospital of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Benfari","sequence":"additional","affiliation":[{"name":"Section of Cardiology, Department of Medicine University of Verona Verona 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