{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T12:09:45Z","timestamp":1771243785803,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T00:00:00Z","timestamp":1720483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T00:00:00Z","timestamp":1720483200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although international guidelines generally recommend the back to back use of short\u2010acting \u03b2\u2010agonists (SABA) within a short time in the management of acute wheezing in children with asthma, there is still uncertainty in the evidence of short term outcome. Thus, this study aimed to investigate the efficacy of back to back and single use of inhaled SABA by lung function testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a prospective, double\u2010blinded, placebo controlled study conducted in children\u2009\u22656 years of age with a history of asthma. Children who presented with an acute asthma exacerbation (AAE) with a forced expiratory volume in 1\u2009s (FEV\n                      <jats:sub>1<\/jats:sub>\n                      ) between 40% to 60% were enrolled in the study if they had a first dose to SABA response of FEV\n                      <jats:sub>1<\/jats:sub>\n                      \u2009\u2265\u200912%. All children were then randomly assigned either to receive two additional doses of inhaled SABA (300\u2009\u00b5g per dose) or placebo. Spirometric analysis included forced vital capacity (FVC), FEV\n                      <jats:sub>1<\/jats:sub>\n                      , FEV\n                      <jats:sub>1<\/jats:sub>\n                      \/FVC, PEF, and FEF\n                      <jats:sub>25\u221275<\/jats:sub>\n                      at baseline, 15, 30, and 45\u2009min for each group. Oxygen saturation and heart rate were monitored during the study period.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 93 patients (inhaled SABA group;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200948 vs. placebo group;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200945) out of 110 enrolled patients completed the study. Baseline demographic characteristics of patients include age, gender, age of diagnosis, parental asthma, history of allergic rhinitis and atopic dermatitis, current asthma treatment, IgE and skin prick test were similar among groups. (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u2009.05) When lung function parameters were compared at each time interval during the study period, there were no statistical significance found in FVC, FEV\n                      <jats:sub>1<\/jats:sub>\n                      , FEV\n                      <jats:sub>1<\/jats:sub>\n                      \/FVC, PEF and forced expiratory flow between 25% and 75% (FEF\n                      <jats:sub>25\u221275<\/jats:sub>\n                      ) among groups. (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u2009.05) There were also no differences between groups for changes in heart rate and oxygen saturation. (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u2009.05)\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      A single dose of inhaled SABA provides similar short term bronchodilator effect as back to back administration of inhaled SABA in children with AAE who showed an initial response to SABA of FEV\n                      <jats:sub>1<\/jats:sub>\n                      \u2009\u2265\u200912%.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.27171","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T14:56:44Z","timestamp":1720537004000},"page":"3190-3196","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Once or consecutive administration of inhaled salbutamol in children with acute asthma exacerbation: Is an additional dose beneficial?"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7340-0409","authenticated-orcid":false,"given":"Ali","family":"\u00d6zdemir","sequence":"first","affiliation":[{"name":"Department of Pediatrics University Of Health Sciences Mersin City Training &amp; Research Hospital Turkey Mersin Turkey"},{"name":"Pediatric Pulmonary Section University Of Health Sciences Mersin City Training &amp; Research Hospital Turkey Mersin Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Ersoy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University Of Health Sciences Mersin City Training &amp; Research Hospital Turkey Mersin Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ay\u015fe Kirmizita\u015f","family":"Aydo\u011fdu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University Of Health Sciences Mersin City Training &amp; Research Hospital Turkey Mersin Turkey"},{"name":"Pediatric Allergy Section University Of Health Sciences Mersin City Training &amp; Research Hospital Turkey Mersin Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-020-01231-6"},{"key":"e_1_2_10_3_1","first-page":"321","article-title":"How much do we know about atopic asthma: where are we now?","volume":"3","author":"Ying S","year":"2006","journal-title":"Cell Mol Immunol"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)33311-1"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-018-0481-1"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006205-200609000-00008"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006565-200212000-00010"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1553-2712.1996.tb03346.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.SMJ.0000054423.65076.75"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13039"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01499-2021"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.26.9part2.148S"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/02770903.2015.1067323"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0b013e3182809b48"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.10083"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000314"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/02770903.2020.1723622"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.83.4.513"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/ewjm.172.4.247"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph3041016"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(90)90113-M"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.27171","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ppul.27171","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.27171","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T11:22:08Z","timestamp":1771240928000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.27171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,9]]},"references-count":20,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1002\/ppul.27171"],"URL":"https:\/\/doi.org\/10.1002\/ppul.27171","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,9]]},"assertion":[{"value":"2023-12-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}