{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T19:53:34Z","timestamp":1776714814800,"version":"3.51.2"},"reference-count":21,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T00:00:00Z","timestamp":1722988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T00:00:00Z","timestamp":1722988800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Immune\u2010based therapy targeting immunoglobulin E (IgE), anti\u2010IgE treatment, has emerged as an adjunct treatment for children with severe allergic asthma. After start of anti\u2010IgE treatment, an effect of the treatment cannot be monitored by Total\u2010IgE, because current methods measure both bound and free IgE molecules. Basophil activation test may be very useful for monitoring anti\u2010IgE treatment efficacy. The objective of this paper is to evaluate if basophil activation test is applicable in regulating the anti\u2010IgE treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A case series of 20 children with IgE\u2010mediated severe allergic asthma were treated according to guidelines with anti\u2010IgE (Omalizumab). Blood samples were drawn for total IgE, specific IgE, number of IgE receptors (Fc\u03b5RI) and basophil sensitivity were measured at baseline before anti\u2010IgE treatment and 4 months after initiation of anti\u2010IgE treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 19 out of 20 children had statistically significant and clinically relevant effects of anti\u2010IgE treatment on symptom score, lung function and medication. All 20 children had a significant reduction in basophil allergen sensitivity and the number of IgE receptors (Fc\u03b5RI) on blood basophils. Anti\u2010IgE treatment was found to be well controlled by measuring basophil allergen sensitivity and FceRI density on blood basophils.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This cohort study demonstrates a promising method, measuring basophil allergen sensitivity and in particular blood basophil FceRI density, concerning the monitoring of anti\u2010IgE treatment in different clinical situations. There are no randomized controlled trials evaluating this method in clinical settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.27206","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T09:10:52Z","timestamp":1723021852000},"page":"3355-3363","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Basophil FceRI expression\u2014A management tool in anti\u2010IgE treatment of allergic asthma"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7010-2350","authenticated-orcid":false,"given":"Sune Leisgaard M\u00f8rck","family":"Rubak","sequence":"first","affiliation":[{"name":"Department of Child and Adolescent Health, Center of Pediatric Pulmonology and Allergology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4583-3210","authenticated-orcid":false,"given":"Nadja Lindberg","family":"Bonne","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Health Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1409-0516","authenticated-orcid":false,"given":"Britta Eilertsen","family":"Hjerrild","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Health, Center of Pediatric Pulmonology and Allergology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6743-7931","authenticated-orcid":false,"given":"Hans J\u00fcrgen","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Department of Clinical Immunology, Aarhus University Hospital Aarhus University Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009705"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.09.008"},{"key":"e_1_2_9_4_1","unstructured":"Medicinr\u00e5det Omalizumab.https:\/\/medicinraadet.dk\/media\/crhplg4b\/medicinr\u00e5dets\u2010l\u00e6gemiddelrek\u2010og\u2010beh\u2010vejl\u2010vedr\u2010sv\u00e6r\u2010astma\u2010vers\u20102\u20101.pdf 2022."},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2012.05.016"},{"key":"e_1_2_9_6_1","unstructured":"Omalizumab produktresume."},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01476.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.00987.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2012.07.010"},{"key":"e_1_2_9_10_1","first-page":"38","article-title":"Longitudinal study of the expression of Fc\u03b5RI and IgE on basophils and dendritic cells in association with basophil function in two patients with severe allergic asthma treated with Omalizumab","volume":"47","author":"Pereira Santos MC","year":"2015","journal-title":"Eur Ann Allergy Clin Immunol"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/iid3.225"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-016-0633-6"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15957"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12698"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2011.01260.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2010.07.011"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2011.03763.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2020.104215"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12862"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02144.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15907"},{"key":"e_1_2_9_22_1","unstructured":"SchmidJM. Changes in Allergen Specific Immunoglobulins and Basophil Sensitivity during Subcutaneous Immunotherapy in Grasspollen Allergic Subjects: PhD Dissertation. Health Aarhus University 2015."}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.27206","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ppul.27206","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.27206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T11:21:54Z","timestamp":1771240914000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.27206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,7]]},"references-count":21,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1002\/ppul.27206"],"URL":"https:\/\/doi.org\/10.1002\/ppul.27206","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,7]]},"assertion":[{"value":"2024-04-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}